{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T06:34:42Z","timestamp":1793255682241,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:00:00Z","timestamp":1662076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA1101200"],"award-info":[{"award-number":["2021YFA1101200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171048"],"award-info":[{"award-number":["82171048"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purposes<\/jats:title><jats:p>The purpose of this study is to quantify the alteration of retinal peripapillary microvasculature and structure in unilateral indirect traumatic optic neuropathy (ITON) and figure out predicted factors of visual improvement for ITON patients with endoscopic trans\u2010ethmosphenoid optic canal decompression (ETOCD) after one month.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty healthy controls and 72 unilateral ITON patients were included. Optical coherence tomography angiography was used to analyse radial peripapillary capillary (RPC) density, peripapillary retinal nerve fibre layer (pRNFL) thickness, superficial retinal capillary plexus (SRCP) and deep retinal capillary plexus (DRCP) density. Associations between preoperative parameters and postoperative best\u2010corrected visual acuity (BCVA) were determined. The receiver operating characteristic (ROC) curves were used to figure out predicted factors of visual improvement for ITON after ETOCD one month.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In ITON eyes, the preoperative global RPC density, pRNFL thickness and SRCP density were reduced compared with unaffected eyes (<jats:italic>p<\/jats:italic>\u00a0\u2264\u20090.001). Multivariate linear regression showed that preoperative global RPC density (Standardized<jats:italic>\u03b2<\/jats:italic>\u00a0=\u2009\u22120.273), SRCP density (Standardized<jats:italic>\u03b2<\/jats:italic>\u00a0=\u2009\u22120.183), DRCP density (Standardized<jats:italic>\u03b2<\/jats:italic>\u00a0=\u2009\u22120.098) and preoperative BCVA (Standardized<jats:italic>\u03b2<\/jats:italic>\u00a0=\u20090.795) were associated with the postoperative BCVA (All<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The area under the curve (AUC) of preoperative global RPC density to predict visual improvement after ETOCD was 0.816, while the AUCs of preoperative BCVA, global pRNFL thickness, SRCP and DRCP density were 0.575, 0.756, 0.516 and 0.615, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The alteration of peripapillary area, especially the reduced RPC density, occurred in ITON eyes. The preoperative RPC density was associated with postoperative BCVA and was shown to be highly predictive for visual improvement after ETOCD one month.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.15243","type":"journal-article","created":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T11:49:49Z","timestamp":1662119389000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Retinal peripapillary microvasculature in indirect traumatic optic neuropathy predicted prognosis of endoscopic trans\u2010ethmosphenoid optic canal decompression"],"prefix":"10.1111","volume":"101","author":[{"given":"Jie","family":"Ye","sequence":"first","affiliation":[{"name":"School of Ophthalmology and Optometry and Eye Hospital Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Ophthalmology and Optometry and 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