{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T03:10:21Z","timestamp":1785813021796,"version":"3.56.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T00:00:00Z","timestamp":1664236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009898","name":"Beckett-Fonden","doi-asserted-by":"publisher","award":["21\u20102\u201074\u201029"],"award-info":[{"award-number":["21\u20102\u201074\u201029"]}],"id":[{"id":"10.13039\/501100009898","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010347","name":"Fabrikant Einar Willumsens Mindelegat","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000615","name":"Fight for Sight UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000615","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005860","name":"Helsefonden","doi-asserted-by":"publisher","award":["21\u2010B\u20100403"],"award-info":[{"award-number":["21\u2010B\u20100403"]}],"id":[{"id":"10.13039\/501100005860","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008267","name":"Kong Christian den Tiendes Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008267","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008273","name":"\u00d8jenfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008273","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001734","name":"K\u00f8benhavns Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001734","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To examine the prevalence and risk factors for hypothalamus\u2013pituitary\u2013adrenal axis suppression (HPA axis suppression) in infants receiving glucocorticoid (GC) eye drops after ocular surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a clinical observational cohort study. Children under the age of two receiving GC eye drops after cataract or glaucoma surgery between 1 January 2017 and 31 December 2021 were included at one centre. Medical history and results of the adrenocorticotropic hormone (ACTH) stimulation tests were obtained through patient charts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010nine infants were included in the study. Ten out of 22 patients (45.5%) tested during treatment and two out of 27 patients (7.4%) tested after treatment cessation were diagnosed with HPA axis suppression. The duration of HPA axis suppression extended beyond 3\u2009months in 8 out of 12 patients. Logistic regression showed that infants with HPA axis suppression had received a higher GC dose\/body weight\/day before the first ACTH test (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001). There was a 79% (95% CI:1.28;2.50) increase in the odds of having HPA axis suppression for a 0.01\u2009mg GC increase\/kg\/day corresponding to an additional daily eye drop for an infant weighing 5\u00a0kg. There was an association between HPA axis suppression and number of days from surgery to test (<jats:italic>p<\/jats:italic>\u00a0=\u20090.003), age at surgery (<jats:italic>p<\/jats:italic>\u00a0=\u20090.035) and cumulated GC dose (<jats:italic>p<\/jats:italic>\u00a0=\u20090.005). Three infants with HPA axis suppression had affected growth and one had Cushing\u2010like features, but there were no cases of Addisonian crisis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Infants are at risk of having hypothalamus\u2013pituitary\u2013adrenal axis suppression if they receive a high daily glucocorticoid dose per weight by topical ocular administration. Infants receiving glucocorticoids after ocular surgery should be monitored clinically or by ACTH testing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.15253","type":"journal-article","created":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T10:54:16Z","timestamp":1664276056000},"page":"229-235","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prevalence and risk factors for hypothalamus\u2013pituitary\u2013adrenal axis suppression in infants receiving glucocorticoid eye drops after ocular surgery"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9887-6331","authenticated-orcid":false,"given":"Diana C.","family":"Schmidt","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Copenhagen University Hospital, Rigshospitalet\u2010Glostrup  Glostrup 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