{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T23:25:37Z","timestamp":1771543537365,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T00:00:00Z","timestamp":1663545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The aim of the present study was to determine whether microperimetric parameters could predict the progression of an eye at high risk of age\u2010related macular degeneration (AMD) at 24\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a multicentric prospective non\u2010comparative open\u2010label study including patients with one eye in stage 4 of the Age\u2010Related Eye Disease Study Group (AREDS) classification, and the other eye in AREDS stage 3 (study eye). A microperimetry examination (MAIA\u2122, CenterVue, Padova, Italy) was performed at baseline and every 6\u00a0months during the 2\u2010year follow\u2010up. At the end of the follow\u2010up, each study eye was classified as \u2018progressive\u2019 (i.e. AREDS stage 4) or \u2018non\u2010progressive\u2019 (i.e. AREDS stage 3).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 147 patients were analysed, of which 30.6% progressed from AREDS stage 3 to stage 4. The microperimetry criterion \u2018mean retinal sensitivity\u2019 was significantly different at baseline between non\u2010progressive and progressive eyes (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.022), with lower values for the latter. With a threshold for mean retinal sensitivity set at 24.7\u00a0dB, diagnostic sensitivity was 80% [95%CI (65.4\u201390.4)], specificity was 30.4% [95%CI (21.7\u201340.3)], positive predictive value was 33.6% [95%CI (24.8\u201343.4)], and negative predictive value was 77.5% [95%CI (61.5\u201389.2)]. In the multivariate analysis including microperimetric parameters and other routine ophthalmologic examinations, mean retinal sensitivity was the only predictive parameter statistically associated with progression (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings are encouraging as regards the use of microperimetry, and mean retinal sensitivity value in particular, to predict the 2\u2010year risk of progression to AREDS stage 4 eye.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.15260","type":"journal-article","created":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T08:53:34Z","timestamp":1663577614000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Microperimetry to predict disease progression in eyes at high risk of age\u2010related macular degeneration disease: The <scp>PREVISION<\/scp> 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