{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T20:15:22Z","timestamp":1775592922713,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T00:00:00Z","timestamp":1665446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K09840"],"award-info":[{"award-number":["20K09840"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The purpose of the study was to investigate clinical relevance of fibrin membranous structure (FMS) in the photoreceptor outer segments on spectral\u2010domain optical coherence tomography (SD\u2010OCT) in untreated initial\u2010onset acute Vogt\u2010Koyanagi\u2010Harada (VKH) disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical charts of 39 patients (78 eyes) diagnosed with initial\u2010onset VKH disease were retrospectively reviewed. Age, gender, period from the onset of symptoms to first visit, visual acuity (VA), intraocular pressure (IOP), anterior chamber cells, serous retinal detachment (SRD), SD\u2010OCT findings, as well as fluorescein (FA), and indocyanine green angiography (ICGA) were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>FMS was observed in 24 out of 39 VKH patients in either eye (61.5%). VKH patients with FMS (FMS group) were significantly younger and had the shorter period from the onset of symptoms to the first visit compared with those without FMS (non\u2010FMS group). Mean logMAR VA and proportion of pooling of dye, mean central retinal thickness (CRT) were significantly higher in FMS group than in non\u2010FMS group. In contrast, hyperfluorescence of the optic disc on FA was more in non\u2010FMS group than in FMS group. Significant positive correlations between CRT and logMAR VA or IOP were only observed in the FMS group. Total amount of corticosteroids was significantly greater in FMS group than in non\u2010FMS group. However, there were no significant differences in LogMAR VA and IOP between two groups at 6\u00a0months after treatment initiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>FMS on SD\u2010OCT is a critical feature observed in the early stage of initial\u2010onset acute VKH disease, which is more common in younger patients and is related to the disease activity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.15268","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T07:43:31Z","timestamp":1665474211000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical relevance of fibrin membranous structures in the intra\u2010photoreceptor outer segment separation on spectral domain optical coherence tomography (<scp>SD\u2010OCT<\/scp>) in initial\u2010onset acute <scp>Vogt\u2010Koyanagi\u2010Harada<\/scp> disease"],"prefix":"10.1111","volume":"101","author":[{"given":"Shuntaro","family":"Motegi","sequence":"first","affiliation":[{"name":"Department of Ophthalmology National Defense Medical College  Tokorozaw Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Nagura","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology National Defense Medical College  Tokorozaw Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Yoneda","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology National Defense Medical College  Tokorozaw Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kozo","family":"Harimoto","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology National Defense Medical College  Tokorozaw 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