{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T23:30:08Z","timestamp":1784590208789,"version":"3.55.0"},"reference-count":61,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81904302"],"award-info":[{"award-number":["81904302"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The purpose of the study was to assess the efficacy of electroacupuncture on dry eye (DE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty\u2010four DE patients were randomly assigned to receive electroacupuncture (EAG) three times a week or 0.1% sodium hyaluronate artificial tears (ATG) four times per day for 4\u2009weeks. The primary outcomes were non\u2010invasive tear film breakup time (NIBUT) and tear meniscus height (TMH). The secondary outcomes included the ocular surface disease index (OSDI), Schirmer I test (SIT), corneal sodium fluorescein staining (CFS) score, corneal topography descriptors surface asymmetry index (SAI) and surface regularity index (SRI), corneal sensitivity, 36\u2010item Short\u2010form Health Survey (SF\u201036) score and Hospital Anxiety and Depression Scale (HADS) score. All outcomes were assessed at Week 0 (baseline), Week 4 (after\u2010treatment) and Week 8 (follow\u2010up).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between\u2010group comparisons showed significant differences in the changes in NIBUT (Week 4, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.003; Week 8, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.008), TMH (Week 4, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.014; Week 8, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.009), OSDI (Week 4, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.029; Week 8, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.022), CFS score (Week 8, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.036) and SF\u201036 role\u2010physical score (Week 4, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.010), favouring EAG. Mean changes in SIT, SAI, SRI, corneal sensitivity and HADS scores were statistically equal between the two groups (all <jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). Treatment with electroacupuncture was well\u2010tolerated and showed minimal adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Compared with artificial tears, electroacupuncture shows superior efficacy in improving tear film stability and symptoms of DE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.15271","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T07:50:43Z","timestamp":1665993043000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effects of electroacupuncture on dry eye: A pilot randomized controlled trial"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9739-6106","authenticated-orcid":false,"given":"Guang","family":"Yang","sequence":"first","affiliation":[{"name":"Shanghai Research Institute of Acupuncture and Meridian  Shanghai 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