{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T22:43:21Z","timestamp":1778798601986,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T00:00:00Z","timestamp":1666051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare a treat\u2010and\u2010extend (TAE) strategy with a fixed dosing regimen of intravitreal conbercept (IVC) for the management of treatment\u2010na\u00efve polypoidal choroidal vasculopathy (PCV) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>249 patients with treatment\u2010na\u00efve PCV were randomized 1:1 to fixed dosing regimen with injections every 12\u2009weeks (3\u2009+\u2009Q12W) group or treat\u2010and\u2010extend regimen(3\u2009+\u2009TAE) group. Patients received 3 monthly intravitreal injections of 0.5\u00a0mg conbercept as loading dose in both groups. The 3\u2009+\u2009Q12W patients were monitored monthly and received mandated injections every 12\u2009weeks; the 3\u2009+\u2009TAE patients were monitored and treated monthly until the resolution of exudative disease activity; the interval between visits was then individualized according to study protocol. Visual and anatomical outcomes were compared between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 48\u2009weeks, there was no significant difference between the 3\u2009+\u2009Q12W group and 3\u2009+\u2009TAE group in mean BCVA improvement (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.421), mean changes in central retinal thickness (CRT) (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.818), maximum retinal thickness (MRT) (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.448), pigment epithelial detachment (PED) height (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.221), PED volume (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.076), branching vascular network (BVN) area (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.615), polypoidal lesion number (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.701), polypoidal lesion area (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.424), rates of patients who avoided vision loss of \u226515 ETDRS letters (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.397) or complete polypoidal lesion regression rate (43.8% vs. 41.8%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.814). The 3\u2009+\u2009Q12W group had more decreased retinal haemorrhage area (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.014) and fewer mean numbers of injections comparing with 3\u2009+\u2009TAE group (6.6 vs. 9.4, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Mean maximum extension interval between injections after loading injections was 9.6\u2009\u00b1\u20092.0\u2009weeks for 3\u2009+\u2009TAE group, with 27.8% of patients achieving an extension interval of 12\u2009weeks and 61.1% patients 8\u2009weeks or more.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both 3\u2009+\u2009Q12W and 3\u2009+\u2009TAE regimens of IVC could result in improvement in visual and anatomical outcomes in PCV patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.15272","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T05:51:01Z","timestamp":1666158661000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The comparison of two different strategies of intravitreal conbercept for polypoidal choroidal vasculopathy in Chinese patients results from a <scp>48\u2010week<\/scp> randomized phase 4 study: <scp>STAR<\/scp> study"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0536-2951","authenticated-orcid":false,"given":"Xiaoxin","family":"Li","sequence":"first","affiliation":[{"name":"Xiamen Eye Center of Xiamen University  Xiamen China"},{"name":"Department of Ophthalmology Peking University People's Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6875-8393","authenticated-orcid":false,"given":"Jinfeng","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Peking University People's Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanfang","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The Second Hospital of Jilin University  Jilin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suqin","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Shanghai General Hospital of Shanghai Jiao Tong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology &amp; Visual Science Eye and ENT Hospital of Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srini Vas","family":"Sadda","sequence":"additional","affiliation":[{"name":"Doheny Image Reading Center, Doheny Eye Institute University of California Los Angeles (UCLA) Affiliated  Los Angeles California USA"},{"name":"Department of Ophthalmology David Geffen School of Medicine at University of California Los Angeles  California Los Angeles USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"STAR Study 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