{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T06:26:26Z","timestamp":1773037586262,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T00:00:00Z","timestamp":1666051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of the study was to investigate the prevalence, risk factors and clinical significance of prechoroidal cleft (PC) among neovascular age\u2010related macular degeneration (nAMD) patients in a Caucasian population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A retrospective observational cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 140 patients with naive nAMD were treated with anti\u2010vascular endothelial growth factor (VEGF) injections and a follow\u2010up of \u226524\u2009months. Optical coherence tomography (OCT) scans were graded for the presence of PC, central subfield foveal thickness (CSFT), maximal retinal thickness (MRT), pigment epithelial detachment (PED), presence of intraretinal fluid (IRF), subretinal fluid (SRF) and subretinal hyper\u2010reflective material (SHRM) at baseline, 3, 6, 12 and 24\u2009months. Best corrected visual acuity (BCVA) and anti\u2010VEGF treatments were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 140, 21 eyes (15%) developed PC. BCVA improved significantly from 0.68\u2009\u00b1\u20090.56 to 0.62\u2009\u00b1\u20090.59 logMAR after 24\u2009months (<jats:italic>p<\/jats:italic>\u00a0=\u20090.008). The change in BCVA was not related to the presence of cleft (<jats:italic>p<\/jats:italic>\u00a0=\u20090.208). Multivariate analysis confirmed that higher baseline CSFT (<jats:italic>p<\/jats:italic>\u00a0=\u20090.011, OR\u00a0=\u00a01.004, 95%, CI 1.001\u20131.007) and the presence of multi\u2010layered PED (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001, OR\u00a0=\u00a021.153, 95%, CI 5.591\u201380.026) were both predictive for development of PC. Eyes with PC received more injections than eyes without PC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prechoroidal cleft was found in 15% of Caucasian nAMD patients treated with anti\u2010VEGF injections and was related to greater retinal and PED height, as well as presence of multi\u2010layered PED. Eyes with PC required more anti\u2010VEGF injections. The presence of PC correlates with disease activity, and intensive anti\u2010VEGF suppression can preserve vision.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.15273","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T05:45:13Z","timestamp":1666158313000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Risk factors and clinical significance of prechoroidal cleft in eyes with neovascular age\u2010related macular degeneration in Caucasian patients"],"prefix":"10.1111","volume":"101","author":[{"given":"Gili","family":"Kredi","sequence":"first","affiliation":[{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Ophthalmology Division Tel Aviv Medical Center  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matias","family":"Iglicki","sequence":"additional","affiliation":[{"name":"Private Retina Practice University of Buenos 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