{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:42:18Z","timestamp":1747183338111,"version":"3.40.5"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The purpose of the study was to investigate the association of platelet parameters and postnatal weight gain with treatment\u2010requiring ROP (TR\u2010ROP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective matched case\u2013control study, infants with TR\u2010ROP were individually matched, according to gestational age and birth weight, with one or two untreated infants who developed no or spontaneously regressed ROP. Longitudinal data on platelet count (PLT), mean platelet volume (MPV), daily weight and platelet transfusions were collected. Platelet mass index (PMI) and weight standard deviation score (WSDS) were also calculated. Conditional logistic regression analysis was performed to adjust for matching.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fourteen cases, presenting type I ROP, and 25 matched controls were included. The odds of developing TR\u2010ROP decreased as PLT increased during 31<jats:sup>st<\/jats:sup> week of postmenstrual age (PMA) or during 1<jats:sup>st<\/jats:sup> and 2<jats:sup>nd<\/jats:sup> week of postnatal age (PNA). The odds of developing TR\u2010ROP were 16.7 times higher in infants receiving at least one platelet transfusion compared with those who were not transfused. The odds of developing TR\u2010ROP increased by 31.2% as the mean volume of platelet transfusion per infant increased by 1\u00a0ml. The odds of developing TR\u2010ROP decreased as PMI increased during 1<jats:sup>st<\/jats:sup> week PNA, and as weight and WSDS increased during 4<jats:sup>th<\/jats:sup>\u20136<jats:sup>th<\/jats:sup> week PNA. Analysis of MPV, number of thrombopenic episodes per infant, number of platelet transfusions per infant and days with WSDS &lt; \u22122 showed no association with TR\u2010ROP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>To our knowledge, this is the first study ascertaining an association of platelet transfusions with type I ROP. Prospective cohort studies are required to confirm our findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.15302","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T13:56:29Z","timestamp":1670248589000},"page":"433-442","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Is thrombocytopenia and postnatal weight gain associated with treatment\u2010requiring retinopathy of prematurity? 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