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In a subsequent retrospective cohort study of Utah XFS\/XFG patients and population controls, the risk of AAA was examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>EMR of a statewide healthcare population were obtained from the Utah Population Database (UPDB) which links decades of medical records with Utah demographic and vital records data. In a pilot study, 7167 patients ages \u226540\u2009years identified with AAA diagnosed from 1996 to 2015, based on International Classification of Diseases (ICD) version 9\/10 codes, were included. A univariable hazards model was used to determine the risk of XFS\/XFG in AAA patients. An XFS\/XFG outcome based on ICD 9\/10 codes in AAA patients and in 5:1 sex\u2010 and age\u2010matched non\u2010AAA controls was determined. A retrospective cohort of 3412 XFS\/XFG patients ages \u226550\u2009years diagnosed from 1996 to 2020 and 10 227 3:1 sex\u2010 and age\u2010matched controls who underwent \u22651 dilated eye examination(s) were recently identified and updated diagnoses of AAA were obtained. Multivariable logistic regression was used to estimate AAA risk in XFS\/XFG patients compared with controls. In a subset of XFS\/XFG patients, chart reviews were conducted to confirm clinically diagnosed AAA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the AAA pilot, 20 patients (0.3%) and 118 controls (0.3%) developed XFS\/XFG, respectively. We observed no increased risk of XFS\/XFG in AAA patients compared with non\u2010AAA\u2010matched controls (HR\u00a0=\u00a00.99, 95% CI 0.6\u20131.6). Among XFS\/XFG study patients and controls, 122 patients (3.6%) and 376 controls (3.7%) had an AAA diagnosis. We likewise observed no increased risk of AAA in XFS\/XFG patients (OR\u00a0=\u00a00.97, 95% CI 0.8\u20131.2). In 14 XFS\/XFG patients with an ICD 9\/10 diagnosis of AAA who underwent chart review, a clinical diagnosis of AAA was confirmed in 9 patients (64.3%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings do not support an association between AAA and XFS\/XFG.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.15306","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T04:30:42Z","timestamp":1670992242000},"page":"449-456","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Abdominal aortic aneurysm and exfoliation syndrome in Utah"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2367-1582","authenticated-orcid":false,"given":"Ayesha","family":"Patil","sequence":"first","affiliation":[{"name":"University of Utah Health John A. Moran Eye Center  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6099-1462","authenticated-orcid":false,"given":"Matthew","family":"Conley","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Utah School of Medicine  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Pompoco","sequence":"additional","affiliation":[{"name":"University of Utah Health John A. Moran Eye Center  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chase","family":"Paulson","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Utah School of Medicine  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7832-2638","authenticated-orcid":false,"given":"Samuel","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Utah School of Medicine  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cole","family":"Swiston","sequence":"additional","affiliation":[{"name":"University of Utah Health John A. Moran Eye Center  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer S.","family":"Herrick","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Univerisity of Utah Health  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Ritch","sequence":"additional","affiliation":[{"name":"New York Eye and Ear Infirmary  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Curtin","sequence":"additional","affiliation":[{"name":"University of Utah Health John A. Moran Eye Center  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Wirostko","sequence":"additional","affiliation":[{"name":"University of Utah Health John A. 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