{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T04:24:39Z","timestamp":1772079879598,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T00:00:00Z","timestamp":1671494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>In patients with primary congenital glaucoma (PCG), elevated intraocular pressure (IOP) causes abnormal eye growth. This study compared the outcomes of children with PCG who underwent ab externo trabeculotomy (TROC) at age\u2009\u2264\u20096\u00a0months (early TROC) and of those who underwent TROC at age\u2009&gt;\u20096\u00a0months (delayed TROC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Intraocular pressure, horizontal corneal diameter (HCD), central corneal thickness (CCT) and axial length (AL) were compared before TROC and at 1\u2010, 3\u2010, 6\u2010 and 12\u2010month follow\u2010up visits between the groups of children who underwent TROC until or after 6\u00a0months of age. The ALs of these groups were also compared with the ALs of healthy age\u2010matched eyes examined under the same conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Trabeculotomy was performed in 43 children: 18 (33 eyes) aged 6\u00a0months (group 1) and 25 (37 eyes) aged &gt;6\u00a0months (group 2); the mean ages were 86.56\u2009\u00b1\u200953.64 and 504.48\u2009\u00b1\u2009448.14\u2009days, respectively. The mean pre\u2010 and 12\u2010month postoperative IOP values were 15.97\u2009\u00b1\u20094.78\/16.62\u2009\u00b1\u20094.85 and 9.77\u2009\u00b1\u20092.88\/10.93\u2009\u00b1\u20094.83\u2009mmHg, respectively. Delayed TROC was associated with abnormal AL in 31 (88.6%) out of 37 eyes, while after early TROC, only 13 (41.9%) out of 33 eyes had abnormal AL (chi\u2010square, 8.00; <jats:italic>p<\/jats:italic>\u00a0=\u20090.03). In multivariable analysis, each 1\u2010mmHg increase in preoperative IOP was associated with a 0.25\u2010mmHg increase at 12\u2009months (<jats:italic>p<\/jats:italic>\u00a0=\u20090.04). On average, the mean IOP of the delayed TROC group was higher than that of the early TROC group by 3.72\u2009mmHg at postoperative month 12 (95% CI\u00a0=\u00a00.44\u20136.99; <jats:italic>p<\/jats:italic>\u00a0=\u20090.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Compared with delayed TROC, early TROC is associated with reduced IOP and substantially reduced incidence of abnormal AL at postoperative month 12.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.15310","type":"journal-article","created":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T08:28:55Z","timestamp":1671524935000},"page":"514-520","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Outcomes of early versus delayed trabeculotomy for primary congenital glaucoma"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1466-9963","authenticated-orcid":false,"given":"Sebasti\u00e3o","family":"Cronemberger","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Otorhinolaryngology of the Federal University of Minas Gerais  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Artur W.","family":"Veloso","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Otorhinolaryngology of the Federal University of Minas Gerais  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Lins","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Otorhinolaryngology of the Federal University of Minas Gerais  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Catarina","family":"Melo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Otorhinolaryngology of the Federal University of Minas Gerais  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre Higino Gon\u00e7alves","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Otorhinolaryngology of the Federal University of Minas Gerais  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana","family":"de Figueiredo Barbosa","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Otorhinolaryngology of the Federal University of Minas Gerais  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcio Placedino","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Otorhinolaryngology of the Federal University of Minas Gerais  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,20]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1","volume-title":"GeneReviews\u00ae","author":"Abu\u2010Amero K.K.","year":"2004"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-006-0415-2"},{"issue":"2","key":"e_1_2_7_4_1","first-page":"105","article-title":"Resultados press\u00f3ricos a longo prazo do tratamento do glaucoma cong\u00eanito prim\u00e1rio","volume":"60","author":"Betinjane A.J.","year":"2001","journal-title":"Revista Brasileira de Oftalmologia"},{"key":"e_1_2_7_5_1","first-page":"251","volume-title":"Oftalmologia Pedi\u00e1trica","author":"Calixto N.","year":"2006"},{"key":"e_1_2_7_6_1","first-page":"341","article-title":"Megaloc\u00f3rnea. 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