{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T15:27:23Z","timestamp":1771342043994,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T00:00:00Z","timestamp":1674777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the relationship between subjective (slit lamp examination [SLE]) and objective (densitometry) measurements of corneal haze after accelerated corneal crosslinking (aCXL), assess the relationship between densitometry and corrected distance visual acuity (CDVA), and determine the effect of baseline characteristics on densitometry after aCXL in eyes with progressive keratoconus and other ectasias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Kensington Eye Institute and Bochner Eye Institute, Toronto, Canada.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective analysis of a prospective interventional cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Scheimpflug\u2010derived corneal densitometry, CDVA, maximum keratometry (<jats:italic>K<\/jats:italic><jats:sub>max<\/jats:sub>), and central corneal thickness were measured preoperatively and up to 1\u00a0year after aCXL, and post\u2010operative haze was estimated with SLE (<jats:italic>n<\/jats:italic>\u00a0=\u00a0483 eyes). A random effect model was used to examine the relationship between post\u2010operative subjective haze with SLE and densitometry. Linear mixed models were used to examine the relationship between densitometry, pre\u2010operative baseline characteristics, and CDVA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a significant association between subjective haze with SLE and densitometry (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). There was a significant relationship between CDVA and densitometry: for every 10 GSUs of increased densitometry in the 0\u20132\u2009mm zone, CDVA worsened by approximately half a Snellen line (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Age and pre\u2010operative <jats:italic>K<\/jats:italic><jats:sub>max<\/jats:sub> were significant predictors of densitometry. For every 10\u2009years of age, densitometry increased by 0.68 GSUs (95% CI [0.27 to 1.07], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). For every 10 D of increased preoperative <jats:italic>K<\/jats:italic><jats:sub>max<\/jats:sub>, densitometry increased by 0.69 GSUs (95% CI [0.41 to 0.98], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Subjective haze after aCXL estimated with SLE, is significantly associated with densitometry. Increased densitometry after aCXL is associated with a reduction in CDVA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.15639","type":"journal-article","created":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T06:02:14Z","timestamp":1674885734000},"page":"568-574","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Subjective and objective evaluation of corneal haze after accelerated corneal crosslinking for corneal ectasias"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8523-6121","authenticated-orcid":false,"given":"Rebecca","family":"Stein","sequence":"first","affiliation":[{"name":"Kensington Eye Institute  Toronto Ontario Canada"},{"name":"Department of Ophthalmology and Vision Sciences University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8619-1490","authenticated-orcid":false,"given":"Stephan","family":"Ong\u00a0Tone","sequence":"additional","affiliation":[{"name":"Kensington Eye Institute  Toronto Ontario Canada"},{"name":"Department of Ophthalmology and Vision Sciences University of Toronto  Toronto Ontario Canada"},{"name":"Kensington Crosslinking Working Group  Toronto Ontario Canada"},{"name":"Sunnybrook Health Sciences Centre and Sunnybrook Research Institute  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"Lebovic","sequence":"additional","affiliation":[{"name":"St. Michael's Hospital  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neera","family":"Singal","sequence":"additional","affiliation":[{"name":"Kensington Eye Institute  Toronto Ontario Canada"},{"name":"Department of Ophthalmology and Vision Sciences University of Toronto  Toronto Ontario Canada"},{"name":"Kensington Crosslinking Working Group  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy","family":"Hatch","sequence":"additional","affiliation":[{"name":"Kensington Eye Institute  Toronto Ontario Canada"},{"name":"Department of Ophthalmology and Vision Sciences University of Toronto  Toronto Ontario 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