{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T02:27:21Z","timestamp":1789180041242,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T00:00:00Z","timestamp":1678665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006360","name":"Bundesministerium f\u00fcr Wirtschaft und Energie","doi-asserted-by":"publisher","award":["16KN046458"],"award-info":[{"award-number":["16KN046458"]}],"id":[{"id":"10.13039\/501100006360","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006360","name":"Bundesministerium f\u00fcr Wirtschaft und Energie","doi-asserted-by":"publisher","award":["16KN046460"],"award-info":[{"award-number":["16KN046460"]}],"id":[{"id":"10.13039\/501100006360","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess the safety and performance of hyaluronic acid\u2010based vitreous substitutes in phthitic eyes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective interventional study a total of 21 eyes from 21 patients with phthisis bulbi were treated at the Eye Clinic Sulzbach between August 2011 and June 2021. Patients who underwent a 23G pars plana vitrectomy received a vitreous substitute composed of (I) a non\u2010crosslinked hyaluronic acid (Healon GV), (II) a crosslinked hyaluronic acid\u2010based hydrogel (UVHA), or (III) silicone oil (SO\u20105000). Main outcome measures were the intraocular pressure (IOP), the visual acuity and the structural integrity of the retina and choroid assessed by optical coherence tomography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An increase in IOP\u2009\u2265\u20095\u2009mmHg was achieved with SO\u20105000 in 5\/8 eyes (6\/10 interventions, 60.0%) for 36.4\u2009\u00b1\u200939.5\u2009days, with Healon GV in 4\/8 eyes (7\/11 interventions, 63.6%) for 82.6\u2009\u00b1\u200992.5\u2009days and with UVHA in 4\/5 eyes (5\/6 interventions, 83.3%) for 93.6\u2009\u00b1\u200992.5\u2009days. Visual acuity increased in 5\/21 eyes (23.8%), remained constant in 12\/21 eyes (57.1%) and decreased in 4\/21 eyes (19.0%). No enucleations were required during the mean follow\u2010up time of 192\u2009\u00b1\u2009182\u2009days. The OCT images indicated the preservation of retinal structures, while choroidal folds were only diminished in UVHA eyes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hyaluronic acid\u2010based hydrogels are biocompatible vitreous substitutes in humans and can increase and stabilize IOP in patients with phthisis bulbi for about 3\u2009months.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.15658","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T15:26:02Z","timestamp":1678721162000},"page":"687-695","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Safety and performance assessment of hyaluronic acid\u2010based vitreous substitutes in patients with phthisis bulbi"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2445-9118","authenticated-orcid":false,"given":"Andr\u00e9","family":"Schulz","sequence":"first","affiliation":[{"name":"Eye Clinic Sulzbach, Knappschaft Hospital Saar  Sulzbach Germany"},{"name":"Klaus Heimann Eye Research Institute  Sulzbach Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Wakili","sequence":"additional","affiliation":[{"name":"Eye Clinic Sulzbach, Knappschaft Hospital Saar  Sulzbach Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Januschowski","sequence":"additional","affiliation":[{"name":"Eye Clinic Sulzbach, Knappschaft Hospital Saar  Sulzbach Germany"},{"name":"Klaus Heimann Eye Research Institute  Sulzbach Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner R.","family":"Heinz","sequence":"additional","affiliation":[{"name":"Pharmpur GmbH  K\u00f6nigsbrunn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Engelhard","sequence":"additional","affiliation":[{"name":"Pharmpur GmbH  K\u00f6nigsbrunn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helge","family":"Menz","sequence":"additional","affiliation":[{"name":"Pharmpur GmbH  K\u00f6nigsbrunn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Szurman","sequence":"additional","affiliation":[{"name":"Eye Clinic Sulzbach, Knappschaft Hospital Saar  Sulzbach Germany"},{"name":"Klaus Heimann Eye Research Institute  Sulzbach Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(87)33447-5"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prosdent.2013.08.013"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3928\/0191-3913-19850901-06"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/bit.10605"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.120750"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(13)80572-X"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1993.tb04637.x"},{"key":"e_1_2_6_9_1","unstructured":"D.O.R.C. 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