{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:21:37Z","timestamp":1791559297617,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T00:00:00Z","timestamp":1683244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Optic disc drusen (ODD) are calcium\u2010containing deposits in the optic nerve head, capable of causing visual field defects and sudden visual loss. The underlying pathophysiology remains inadequately understood and treatment options are missing. In this paper, we systematically reviewed prevalence studies of ODD in non\u2010selected populations to provide an overview of its prevalence, conducted meta\u2010analyses to determine modality\u2010specific prevalence estimates and performed a forecasting study to estimate current and future global population number of individuals with ODD. We searched 11 literature databases on 25 October 2022 for prevalence studies of ODD in non\u2010selected populations. Eight eligible studies provided data from a total of 27\u2009463 individuals. Prevalence estimates were stratified according to diagnostic modalities: ophthalmoscopy 0.37% (95% CI: 0.10\u20130.95%), fundus photography 0.12% (95% CI: 0.03\u20130.24%), spectral domain optical coherence tomography with enhanced depth imaging 2.21% (95% CI: 1.25\u20133.42%) and histopathology 1.82% (95% CI: 1.32\u20132.38%). Using histopathology\u2010based summary prevalence estimate, we forecast 145 million individuals with ODD currently, a number expected to increase further due to world population growth. These numbers underscore the importance of including ODD in health education and highlight the necessity of continuing research in ODD.<\/jats:p>","DOI":"10.1111\/aos.15690","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T11:20:38Z","timestamp":1683285638000},"page":"15-24","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Prevalence of optic disc drusen: A systematic review, meta\u2010analysis and forecasting study"],"prefix":"10.1111","volume":"102","author":[{"given":"Hiwa","family":"Mukriyani","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Rigshospitalet  Glostrup Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lasse","family":"Malmqvist","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Rigshospitalet  Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6620-5365","authenticated-orcid":false,"given":"Yousif","family":"Subhi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Rigshospitalet  Glostrup Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Hamann","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Rigshospitalet  Glostrup Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,5]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"91","article-title":"Optic disc drusen and associated venous stasis retinopathy","volume":"66","author":"Austin J.K.","year":"1995","journal-title":"Journal of the American Optometric Association"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech-2013-203104"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2017-311566"},{"key":"e_1_2_7_5_1","first-page":"66","article-title":"Central retinal vein occlusion associated with drusen of the optic disc","volume":"23","author":"Chern S.","year":"1991","journal-title":"Annals of Ophthalmology"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-019-04416-w"},{"key":"e_1_2_7_7_1","first-page":"1","article-title":"Optic disc drusen in children","volume":"189","author":"Erkkil\u00e4 H.","year":"1974","journal-title":"Albrecht von Graefes Archiv f\u00fcr Klinische Und Experimentelle Ophthalmologie"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0000000000000974"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.59.8.413"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.10.035"},{"key":"e_1_2_7_11_1","first-page":"27","article-title":"Central retinal vein occlusion: a prospective histopathologic study of 29 eyes in 28 cases","volume":"1","author":"Green W.R.","year":"1981","journal-title":"Retina"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13748"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2020.03.052"},{"key":"e_1_2_7_14_1","first-page":"2022","article-title":"Cochrane handbook for systematic reviews of interventions version 6.3 (updated February 2022)","author":"Higgins J.P.T.","year":"2022","journal-title":"Cochrane"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyy179"},{"key":"e_1_2_7_16_1","first-page":"1","article-title":"Drusen of the optic disk. 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