{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:40:12Z","timestamp":1747183212966,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:00:00Z","timestamp":1684454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010810","name":"\u00d6gonfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010810","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010817","name":"Stiftelsen Kronprinsessan Margaretas Arbetsn\u00e4mnd f\u00f6r Synskadade","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010817","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001858","name":"VINNOVA","doi-asserted-by":"publisher","award":["2017\u201002447"],"award-info":[{"award-number":["2017\u201002447"]}],"id":[{"id":"10.13039\/501100001858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Glaucoma leads to pathological loss of axons in the retinal nerve fibre layer at the optic nerve head (ONH). This study aimed to develop a strategy for the estimation of the cross\u2010sectional area of the axons in the ONH. Furthermore, improving the estimation of the thickness of the nerve fibre layer, as compared to a method previously published by us.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the 3D\u2010OCT image of the ONH, the central limit of the pigment epithelium and the inner limit of the retina, respectively, were identified with deep learning algorithms. The minimal distance was estimated at equidistant angles around the circumference of the ONH. The cross\u2010sectional area was estimated by the computational algorithm. The computational algorithm was applied on 16 non\u2010glaucomatous subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean cross\u2010sectional area of the waist of the nerve fibre layer in the ONH was 1.97\u2009\u00b1\u20090.19\u2009mm<jats:sup>2<\/jats:sup>. The mean difference in minimal thickness of the waist of the nerve fibre layer between our previous and the current strategies was estimated as CI\u03bc (0.95) 0\u2009\u00b1\u20091\u2009\u03bcm (d.f.\u2009=\u200915).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The developed algorithm demonstrated an undulating cross\u2010sectional area of the nerve fibre layer at the ONH. Compared to studies using radial scans, our algorithm resulted in slightly higher values for cross\u2010sectional area, taking the undulations of the nerve fibre layer at the ONH into account. The new algorithm for estimation of the thickness of the waist of the nerve fibre layer in the ONH yielded estimates of the same order as our previous algorithm.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.15698","type":"journal-article","created":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T06:39:54Z","timestamp":1684564794000},"page":"91-98","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Automatic estimation of the cross\u2010sectional area of the waist of the nerve fibre layer at the optic nerve head"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2271-2036","authenticated-orcid":false,"given":"Konstancija","family":"Kisonaite","sequence":"first","affiliation":[{"name":"Ophthalmology, Surgical Sciences Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaohua","family":"Yu","sequence":"additional","affiliation":[{"name":"Ophthalmology, Surgical Sciences Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9533-1942","authenticated-orcid":false,"given":"Faisal","family":"Raeme","sequence":"additional","affiliation":[{"name":"Ophthalmology, Surgical Sciences Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Bendazzoli","sequence":"additional","affiliation":[{"name":"Biomedical Engineering, Department of Biomedical Engineering and Health Systems KTH Royal Institute of Technology  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunliang","family":"Wang","sequence":"additional","affiliation":[{"name":"Biomedical Engineering, Department of Biomedical Engineering and Health Systems KTH Royal Institute of Technology  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per G.","family":"S\u00f6derberg","sequence":"additional","affiliation":[{"name":"Ophthalmology, Surgical Sciences Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-021-05341-7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","unstructured":"BelghithA BowdC WeinrebRN&ZangwillLM(2014):A hierarchical framework for estimating neuroretinal rim area using 3D spectral domain optical coherence tomography (SD\u2010OCT) optic nerve head (ONH) images of healthy and glaucoma eyes. Presented at the 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society 3869\u20133872.","DOI":"10.1109\/EMBC.2014.6944468"},{"key":"e_1_2_8_4_1","first-page":"1","article-title":"Fully automatic estimation of the waist of the nerve fiber layer at the optic nerve head angularly resolved","volume":"11623","author":"Brusini I.","year":"2021","journal-title":"SPIE Proceedings"},{"key":"e_1_2_8_5_1","first-page":"17","article-title":"Fully automatic estimation of the angular distribution of the waist of the nerve fiber layer in the optic nerve head","volume":"11218","author":"Carrizo G.","year":"2020","journal-title":"SPIE Proceedings"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-1160"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.09.055"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13698"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-20561"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.11.007"},{"key":"e_1_2_8_11_1","first-page":"140","article-title":"Comparison of Optic Nerve Imaging Methods to Distinguish Normal Eyes from those with Glaucoma","volume":"43","author":"Greaney M.J.","year":"2002","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000000250"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(03)00792-X"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1117\/12.2608073"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-021-01906-6"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2017.04.007"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.2773736"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-9309"},{"key":"e_1_2_8_19_1","first-page":"234","volume-title":"Med image Comput Comput\u2010assist Interv \u2013 MICCAI 2015","author":"Ronneberger O.","year":"2015"},{"key":"e_1_2_8_20_1","first-page":"1342","article-title":"The number and diameter distribution of axons in the monkey optic nerve","volume":"27","author":"Sanchez R.M.","year":"1986","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13908"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14197"},{"key":"e_1_2_8_23_1","first-page":"2029","article-title":"Glaucoma detection based on the waist of nerve fiber layer at the optic nerve head, average thickness or cross\u2010sectional area?","volume":"63","author":"S\u00f6derberg P.G.","year":"2022","journal-title":"Investigative Ophthalmology & Visual Science"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.15698","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T05:43:08Z","timestamp":1705556588000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.15698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,19]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1111\/aos.15698"],"URL":"https:\/\/doi.org\/10.1111\/aos.15698","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"type":"print","value":"1755-375X"},{"type":"electronic","value":"1755-3768"}],"subject":[],"published":{"date-parts":[[2023,5,19]]},"assertion":[{"value":"2022-11-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}