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The objective of this paper is to report on the cost\u2010effectiveness of an iOCT\u2010protocol in DMEK surgery with the <jats:italic>Advanced Visualization in Corneal Surgery Evaluation<\/jats:italic> (ADVISE) trial. This cost\u2010effectiveness analysis uses data 6\u2009months postoperatively from the multicentre prospective randomized clinical ADVISE trial. Sixty\u2010five patients were randomized to usual care (<jats:italic>n<\/jats:italic>\u2009=\u200933) or the iOCT\u2010protocol (<jats:italic>n<\/jats:italic>\u2009=\u200932). Quality\u2010Adjusted Life Years (EQ\u20105D\u20105L), Vision\u2010related Quality of Life (NEI\u2010VFQ\u201025) and self\u2010administered resources questionnaires were administered. Main outcome is the incremental cost\u2010effectiveness ratio (ICER) and sensitivity analyses. The iOCT protocol reports no statistical difference in ICER. For the usual care group compared with the iOCT protocol, respectively, the mean societal costs are \u20ac5027 compared with \u20ac4920 (\u0394\u20ac107). The sensitivity analyses report the highest variability on time variables. This economic evaluation learned that there is no added value in quality of life or cost\u2010effectiveness in using the iOCT protocol in DMEK surgery. The variability of cost variables depends on the characteristics of an eye clinic. The added value of iOCT could gain incrementally by increasing surgical efficiency, and aiding in surgical decision\u2010making.<\/jats:p>","DOI":"10.1111\/aos.15729","type":"journal-article","created":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T06:29:21Z","timestamp":1687328961000},"page":"254-262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cost\u2010effectiveness of the ADVISE trial: An intraoperative OCT protocol in DMEK surgery"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2795-2322","authenticated-orcid":false,"given":"Casper","family":"van der Zee","sequence":"first","affiliation":[{"name":"Utrecht Cornea Research Group, Ophthalmology Department University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3341-8302","authenticated-orcid":false,"given":"Marc B.","family":"Muijzer","sequence":"additional","affiliation":[{"name":"Utrecht Cornea Research Group, Ophthalmology Department University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank J. 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