{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:40:19Z","timestamp":1747183219204,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,8,13]],"date-time":"2023-08-13T00:00:00Z","timestamp":1691884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010733","name":"B\u00f8rnecancerfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010733","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010339","name":"Ingeni\u00f8r Otto Christensens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008363","name":"Kr\u00e6ftens Bek\u00e6mpelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate ophthalmic onset manifestations and the impact of diagnostic delay on the prognosis in infants (&lt;1\u2009year) diagnosed with a brain tumour.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective population\u2010based nationwide study of infants diagnosed with a brain tumour between 2007 and 2017 in Denmark. Data was retrieved from the Danish Childhood Cancer Registry, the National Danish Health registries, and medical files. Primary outcome measures included symptoms, clinical findings, time to diagnosis and survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010seven infants were diagnosed with a brain tumour in Denmark between 2007 and 2017. In total, 19\/37 infants (51%, 95% CI: 34\u201368) had ophthalmic manifestations at any time prior to or at diagnosis; and in 6\/37 (16%, 95% CI: 6\u201332) ophthalmic manifestations were the initial symptom. The most common ophthalmic manifestations were strabismus (<jats:italic>n<\/jats:italic>\u2009=\u20097), sunset eyes (<jats:italic>n<\/jats:italic>\u2009=\u20096), nystagmus (<jats:italic>n<\/jats:italic>\u2009=\u20094), reduced pupillary light reflex (<jats:italic>n<\/jats:italic>\u2009=\u20094), and\/or decreased vision (<jats:italic>n<\/jats:italic>\u2009=\u20094). The median number of symptoms per infant at the time of diagnosis was three (range 0\u20139). The median diagnostic delay was 26\u2009days (range 0\u2013283, IQR: 6;90). 5\u2010year survival rate was 75% (95% CI: 61\u201390) and all children with diagnostic delay\u2009&gt;\u2009100\u2009days (<jats:italic>n<\/jats:italic>\u2009=\u20099, 24%) were still alive at the end of follow\u2010up (median 6.3\u2009years, range 2.2\u201310.2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We provide an overview of symptoms and clinical signs in a nation\u2010wide series of infants with CNS tumours and demonstrate that ophthalmic manifestations are frequently observed in infants prior to diagnosis, but, often in combination with other clinical signs. The diagnostic delay was substantial for a large part of the infants, but this was not associated with increased mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.15745","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T03:53:49Z","timestamp":1691985229000},"page":"334-341","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ophthalmic symptoms, clinical signs and diagnostic delay in infants diagnosed with brain tumours in Denmark between 2007 and 2017"],"prefix":"10.1111","volume":"102","author":[{"given":"Nathali J.","family":"Turanzas","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9","family":"Mathiasen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Heegaard","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Copenhagen University Hospital  Copenhagen Denmark"},{"name":"Department of Pathology Copenhagen University Hospital  Copenhagen Denmark"},{"name":"Institute of Clinical Medicine, Faculty of Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kjeld","family":"Schmiegelow","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Copenhagen University Hospital  Copenhagen Denmark"},{"name":"Institute of Clinical Medicine, Faculty of Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid","family":"Sehested","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeppe K.","family":"Holtz","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volkert","family":"Siersma","sequence":"additional","affiliation":[{"name":"The Research Unit for General Practice and Section of General Practice, Department of Public Health University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamilla R.","family":"Nissen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7711-6931","authenticated-orcid":false,"given":"Sarah L.","family":"von Holstein","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Copenhagen University Hospital  Copenhagen Denmark"},{"name":"Institute of Clinical Medicine, Faculty of Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-020-00875-3"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1997.tb46217.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-3384-6"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12730"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-307578"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2016.10.010"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/26.4.404"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-002-1088-4"},{"key":"e_1_2_7_10_1","unstructured":"eSundhed. (2021)The medical birth registry."},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cppeds.2011.12.002"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/1817-1745.174454"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JGO.19.00140"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.4429"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006418506213"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14354"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.8273"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2017.07.006"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2022.3628"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2017.05.032"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073807308692"},{"volume-title":"RStudio: integrated development for R","year":"2020","author":"Rstudio T.","key":"e_1_2_7_22_1"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27063"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp17X688801"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22585"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S99508"},{"key":"e_1_2_7_27_1","unstructured":"StatBank Denmark(2023)."},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2017.3158"},{"key":"e_1_2_7_29_1","unstructured":"WalkerD. GrundyR. KennedyC. CollierJ. WilneS.&KollerK.(2017):The brain pathways guideline: a guideline to assist healthcare professionals in the assessment of children who may have a brain tumour 0\u2013127."},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nov187"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(07)70207-3"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.15745","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T05:00:57Z","timestamp":1712638857000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.15745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,13]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/aos.15745"],"URL":"https:\/\/doi.org\/10.1111\/aos.15745","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"type":"print","value":"1755-375X"},{"type":"electronic","value":"1755-3768"}],"subject":[],"published":{"date-parts":[[2023,8,13]]},"assertion":[{"value":"2022-11-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}