{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:40:23Z","timestamp":1792442423263,"version":"4.5.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T00:00:00Z","timestamp":1694476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010817","name":"Stiftelsen Kronprinsessan Margaretas Arbetsn\u00e4mnd f\u00f6r Synskadade","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010817","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>This study aimed to investigate various aspects of treatment for retinopathy of prematurity (ROP) in Sweden over the past 14\u2009years, nationally and at a hospital level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data on screening and treatment for ROP in infants born in Sweden from 2008 to 2021 were extracted from the national ROP register, SWEDROP. During this period, Swedish screening guidelines were reduced from gestational age (GA)\u2009&lt;\u200932\u2009weeks to &lt;31\u2009weeks in 2012 and to &lt;30\u2009weeks in 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Altogether, 10\u2009959 infants were screened and 600 infants treated for ROP during the study period. Parallel to changed guidelines, the number of screened infants decreased (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.000) and the incidence of ROP and frequency of treatment increased (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), while both remained similar in infants with a GA below 30\u2009weeks. Among treated infants, GA and BW were reduced over the years (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Laser treatment (85.2% of primary treatments) became less common and anti\u2010VEGF injections (13.6%) became more common over time (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Altogether 16 eyes were treated with the encircling band and 13 with vitrectomy. The total frequency of retreatment (32.7% of treated eyes) remained similar over time but was more common after primary anti\u2010VEGF injection (67.7%) than laser treatment (27.2%). There were differences between the seven university hospitals regarding type of treatment and number of retreatments (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The frequency of treatment and retreatment for ROP remained similar over time, but the type of treatment changed and anti\u2010VEGF injections became more common. Differences between treating hospitals emphasize the importance of centralizing the most severe cases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.15751","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T09:33:44Z","timestamp":1694511224000},"page":"401-408","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Treatment for retinopathy of prematurity in Sweden 2008\u20132021: Reduced gestational age of treated infants and remaining differences in treatment type and recurrence rates between hospitals"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5600-7186","authenticated-orcid":false,"given":"Gerd","family":"Holmstr\u00f6m","sequence":"first","affiliation":[{"name":"Department of Surgical Sciences, Ophthalmology Uppsala University  Uppsala 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