{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T16:28:46Z","timestamp":1780072126241,"version":"3.54.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:00:00Z","timestamp":1695081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004326","name":"Bayer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The German Retina.net ROP registry and its Europe\u2010wide successor, the EU\u2010ROP registry, collect data from patients treated for ROP. This analysis compares input parameters of these two registries to establish a procedure for joint analyses of different registry data using exemplary datasets from the two registries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Exemplary datasets from the two databases over a 1\u2010year period each (German Retina.net ROP Registry, 2011, 22 infants; EU\u2010ROP Registry, 2021, 44 infants) were compared. The parameters documented in the two databases were aligned and analysed regarding demographic parameters, treatment modalities, complications within first 24\u2009h and retreatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The current analysis showed that data can be aligned for joint analyses with some adjustments within the data structure. The registry with more detailed data collection (EU\u2010ROP) needs to be reduced regarding granularity in order to align the different registries, as the registry with lower granularity determines the level of analyses that can be performed in a comparative approach. In the exemplary datasets, we observed that the overall most common ROP severity in both registries was zone II, 3+ (2011: 70.5%; 2021: 65%), with decreasing numbers of clock hours showing preretinal neovascularisations (2011: 10\u201312 clock hours in 29% of cases, 2021: 4\u20136 clock hours in 38%). The most prevalent treatment method was laser coagulation in 2011 (75%) and anti\u2010VEGF therapy in 2021 (86.1%). Within the anti\u2010VEGF group, all patients were treated with bevacizumab in 2011 and with ranibizumab in 2021. Retreatment rates were comparable in 2011 and 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Data from two different ROP registries can be aligned and jointly analysed. The analysis reveals a paradigm shift in treatment modalities, from predominantly laser to anti\u2010VEGF, and within the anti\u2010VEGF group from bevacizumab to ranibizumab in Germany. In addition, there was a trend towards earlier treatment in 2021.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.15753","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T16:23:45Z","timestamp":1695140625000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Comparability of input parameters in the German Retina.net ROP registry and the EU\u2010ROP registry \u2013 An exemplary comparison between 2011 and 2021"],"prefix":"10.1111","volume":"102","author":[{"given":"K.","family":"Winter","sequence":"first","affiliation":[{"name":"Department of Ophthalmology University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2731-6094","authenticated-orcid":false,"given":"J. M.","family":"Pfeil","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Engmann","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Aisenbrey","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Vivantes Klinikum Neukoelln  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Lorenz","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Medicine Giessen and Marburg GmbH Giessen Campus  Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Hufendiek","sequence":"additional","affiliation":[{"name":"University Eye Hospital Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Breuss","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology HELIOS Klinikum Berlin\u2010Buch  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Khattab","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Medical Center Goettingen  Goettingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"S\u00fcsskind","sequence":"additional","affiliation":[{"name":"University Eye Hospital Eberhard Karls University of Tuebingen  Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Kakkassery","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Luebeck  Luebeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3558-5905","authenticated-orcid":false,"given":"W. A.","family":"Lagr\u00e8ze","sequence":"additional","affiliation":[{"name":"Eye Center, Medical Center, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Barth","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6352-6259","authenticated-orcid":false,"given":"R.","family":"Liegl","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Medicine Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. C.","family":"Br\u00fcnder","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Skevas","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Goldammer","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Klinikum Chemnitz gGmbH  Chemnitz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Glitz","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Muenster Medical Center  Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Michalewicz","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospital RWTH Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2280-925X","authenticated-orcid":false,"given":"T. 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R.","family":"Bartmann","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Klinikum Fulda, Faculty of Medicine\/Campus Fulda University of Marburg  Fulda Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8013-7597","authenticated-orcid":false,"given":"A.","family":"Stahl","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Retina.net ROP and EU\u2010ROP registry study groups","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00347-021-01528-9"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2021.05.031"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-83985-5"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1007\/s00347-020-01170-x","article-title":"Stellungnahme der Deutschen Ophthalmologischen Gesellschaft, der Retinologischen Gesellschaft und des Berufsverbands der Augen\u00e4rzte Deutschlands zur Anti\u2010VEGF\u2010Therapie der Fr\u00fchgeborenenretinopathie","volume":"117","author":"Deutsche Ophthalmologische Gesellschaft e. 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