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Systemic searches of the Ovid MEDLINE, EMBASE, and Cochrane Library databases yielded experimental and observational comparative studies. TSCPC and CCT efficacy and safety outcomes were compared. Subgroup analyses of participant ethnicity, preoperative intraocular pressure (IOP) level, and underlying causes of glaucoma were conducted. The pooled effects were computed using the random\u2010effects model. The meta\u2010analysis included nine studies totalling 668 eyes. There was no statistically significant difference between the TSCPC and CCT groups in the IOP reduction (IOPR%), decrease in antiglaucoma medications, the operative success rate with or without medications, or retreatment rate in the efficacy analysis. In the subgroup analysis, CCT had a better IOP\u2010lowering effect among non\u2010Asian participants and a non\u2010inferior IOPR% to TSCPC among Asian participants. TSCPC and CCT were associated with similar rates of deterioration in visual acuity, postoperative visual analog scale, and other analysed postoperative complications in the safety analysis. In both groups, severe complications were uncommon. Diode laser TSCPC and CCT had nearly equivalent clinical efficacy in treating intractable glaucoma, while CCT demonstrated a better IOP\u2010lowering effect in non\u2010Asian. Both cyclodestructive procedures have a comparable safety profile.<\/jats:p>","DOI":"10.1111\/aos.15754","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T09:41:39Z","timestamp":1694770899000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Efficacy and safety of transscleral cyclophotocoagulation versus cyclocryotherapy in the treatment of intractable glaucoma: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6153-4709","authenticated-orcid":false,"given":"Shih\u2010Yi","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Taipei City Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chu\u2010Yu","family":"Yen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Taipei City Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo\u2010I","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Taipei City Hospital  Taipei Taiwan"},{"name":"Department of Ophthalmology National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju\u2010Chuan","family":"Yen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Taipei City Hospital  Taipei Taiwan"},{"name":"Department of Education and Research Taipei City Hospital  Taipei Taiwan"},{"name":"Graduate Institute of Biomedical Informatics, College of Medical Science and Technology Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiow\u2010Wen","family":"Liou","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Taipei City Hospital  Taipei Taiwan"},{"name":"Department of Ophthalmology National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Ophthalmology Shin Kong Memorial Wu Ho\u2010Su Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Chen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Taipei City Hospital  Taipei Taiwan"},{"name":"Institute of Clinical Medicine National Yang\u2010Ming University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000001053"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2010.174"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.12360"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.04.015"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.12088"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000001011"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/vision1040024"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.74.2.103"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.4274\/tjo.18559"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogla.2021.01.004"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/112067219500500106"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2016-309946"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7697416"},{"key":"e_1_2_11_15_1","first-page":"1834","article-title":"Neodymium\u2010YAG transscleral cyclophotocoagulation. 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