{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T19:22:25Z","timestamp":1791832945863,"version":"4.3.4"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T00:00:00Z","timestamp":1694390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The Myopia Outcome Study of Atropine in Children (MOSAIC) is an investigator\u2010led, double\u2010masked, randomized controlled trial investigating the efficacy and safety of 0.01% atropine eye drops for managing myopia progression in a predominantly White, European population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Children aged 6\u201316\u2009years with myopia were randomly allocated 2:1 to nightly 0.01% atropine or placebo eye drops in both eyes for 2\u2009years. The primary outcome was cycloplegic spherical equivalent (SE) progression at 24\u2009months. Secondary outcomes included axial length (AL) change, safety and acceptability. Linear mixed models with random intercepts were used for statistical analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 250 participants enrolled, 204 (81.6%) completed the 24\u2010month visit (136 (81.4%) treatment, 68 (81.9%) placebo). Baseline characteristics, drop\u2010out and adverse event rates were similar between treatment and control groups. At 24\u2009months, SE change was not significantly different between 0.01% atropine and placebo groups (effect\u2009=\u20090.10\u2009D,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.07), but AL growth was lower in the 0.01% atropine group, compared to the placebo group (\u22120.07\u2009mm,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007). Significant treatment effects on SE (0.14\u2009D,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.049) and AL (\u22120.11\u2009mm,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) were observed in children of White, but not non\u2010White (SE\u2009=\u20090.05\u2009D,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.89; AL\u2009=\u20090.008\u2009mm,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.93), ethnicity at 24\u2009months. A larger treatment effect was observed in subjects least affected by COVID\u201019 restrictions (SE difference\u2009=\u20090.37\u2009D,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005; AL difference\u2009=\u2009\u22120.17\u2009mm,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Atropine 0.01% was safe, well\u2010tolerated and effective in slowing axial elongation in this European population. Treatment efficacy varied by ethnicity and eye colour, and potentially by degree of COVID\u201019 public health restriction exposure during trial participation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.15761","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T07:23:03Z","timestamp":1694416983000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Myopia outcome study of atropine in children: Two\u2010year result of daily 0.01% atropine in a European population"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3130-8991","authenticated-orcid":false,"given":"James","family":"Loughman","sequence":"first","affiliation":[{"name":"Centre for Eye Research Ireland, School of Physics, Environmental Sustainability and Health Institute Technological University Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5955-7992","authenticated-orcid":false,"given":"Emmanuel","family":"Kobia\u2010Acquah","sequence":"additional","affiliation":[{"name":"Centre for Eye Research Ireland, School of Physics, Environmental Sustainability and Health Institute Technological University Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8957-0733","authenticated-orcid":false,"given":"Gareth","family":"Lingham","sequence":"additional","affiliation":[{"name":"Centre for Eye Research Ireland, School of Physics, Environmental Sustainability and Health Institute Technological University Dublin  Dublin Ireland"},{"name":"Centre for Ophthalmology and Visual Science (incorporating Lions Eye Institute) The University of Western Australia  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5567-8634","authenticated-orcid":false,"given":"John","family":"Butler","sequence":"additional","affiliation":[{"name":"Centre for Eye Research Ireland, School of Physics, Environmental Sustainability and Health Institute Technological University Dublin  Dublin Ireland"},{"name":"School of Mathematical Sciences Technological University Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2438-9036","authenticated-orcid":false,"given":"Ekaterina","family":"Loskutova","sequence":"additional","affiliation":[{"name":"Centre for Eye Research Ireland, School of Physics, Environmental Sustainability and Health Institute Technological University Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7914-4709","authenticated-orcid":false,"given":"David A.","family":"Mackey","sequence":"additional","affiliation":[{"name":"Centre for Ophthalmology and Visual Science (incorporating Lions Eye Institute) The University of Western Australia  Perth Western Australia Australia"},{"name":"Centre for Eye Research Australia University of Melbourne, Royal Victorian Eye and Ear Hospital  East Melbourne Victoria Australia"},{"name":"School of Medicine, Menzies Research Institute Tasmania University of Tasmania  Hobart Tasmania Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6635-1098","authenticated-orcid":false,"given":"Samantha S. 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