{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T12:32:40Z","timestamp":1793968360222,"version":"4.8.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:00:00Z","timestamp":1696464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Evaluation of long\u2010term functional and structural outcomes in patients with primary congenital glaucoma (PCG) based on visual acuity (VA), visual field (VF) using standard automated perimetry, and peripapillary retinal nerve fibre layer thickness (pRNFL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed medical records of all patients diagnosed with PCG in Denmark from 1977 to 2016. Severe vision loss was defined as VA &lt;6\/60 and\/or VF &gt;20 decibels (dB). Prognostic factors were evaluated in a correlation matrix.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age of the 94 patients (153 PCG eyes) was 12\u2009years (IQR 9\u201316). In PCG eyes 62% had VA \u22656\/18 but 22% had &lt;6\/60. VA in the better seeing eye was \u22656\/18 in 90% and &lt;6\/60 in 5%. VF was measured in 59 PCG eyes and the median mean defect was 5.1\u2009dB (IQR 2.1\u20139.6) with 52% better than 6\u2009dB and 9% worse than 20\u2009dB. Generalized pRNFL was reduced below the age\u2010expected 1st percentile in 29% of the 58 PCG eyes where pRNFL was measured. Poor VA, poor VF and reduced pRNFL were all correlated (<jats:italic>p<\/jats:italic>\u2009=\u20090.0001). More surgeries (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and longer diagnostic delay (<jats:italic>p<\/jats:italic>\u2009=\u20090.004) were associated with poorer vision and to a lesser degree with poor VF pRNFL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In Denmark, most patients with bilateral PCG retain VA \u22656\/18 in the better seeing eye. Poor VA was associated with poor VF. Longer diagnostic delay and more surgeries were associated with a poorer prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.15772","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T20:01:42Z","timestamp":1696536102000},"page":"228-237","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Long\u2010term functional and structural outcomes in patients with primary congenital glaucoma\u2014A Danish nationwide study"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5250-4257","authenticated-orcid":false,"given":"Troels","family":"Brynskov","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Copenhagen University Hospital Rigshospitalet\u2010Glostrup Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniella","family":"Bach\u2010Holm","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Copenhagen University Hospital Rigshospitalet\u2010Glostrup Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Kappelgaard","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Copenhagen University Hospital Rigshospitalet\u2010Glostrup Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volkert","family":"Siersma","sequence":"additional","affiliation":[{"name":"Research Unit for General Practice and Section of General Practice, Department of Public Health University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen Bjerg","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Copenhagen University Hospital Rigshospitalet\u2010Glostrup Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9375-1510","authenticated-orcid":false,"given":"Line","family":"Kessel","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Copenhagen University Hospital Rigshospitalet\u2010Glostrup Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e3181c4b0c7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/01658107.2014.902971"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1136\/bjophthalmol-2019-315131","article-title":"Long\u2010term functional outcomes of different subtypes of primary congenital glaucoma","volume":"104","author":"Chaudhary R.S.","year":"2020","journal-title":"British Journal of Ophthalmology"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2010.11.025"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2011-300916"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-021-05185-1"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14619"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-1313.2010.00766.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopthalmol.2011.1576"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pbr.2015.06.005"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-27492007000100007"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494811401482"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.07.044"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14207"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.80.6.515"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2014.12.008"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12834"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1091-8531(99)70028-5"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000516"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14846"},{"key":"e_1_2_6_22_1","unstructured":"World Health Organization. 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