{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T03:02:39Z","timestamp":1785466959355,"version":"3.56.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T00:00:00Z","timestamp":1696032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100016309","name":"Bayer, United Kingdom","doi-asserted-by":"publisher","award":["Investigator\u2010led Independent grant"],"award-info":[{"award-number":["Investigator\u2010led Independent grant"]}],"id":[{"id":"10.13039\/100016309","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Data are limited pertaining to the long\u2010term benefits of aflibercept treatment for neovascular age\u2010related macular degeneration (nAMD). The aim of this study was to provide outcomes, safety, durability and quality\u2010of\u2010life data with aflibercept using a modified treat, extend and fixed regime over 4\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective, multicentre, single cohort observational study of treatment\u2010na\u00efve nAMD participants treated with aflibercept as 2\u2010year extension of the MATE\u2010trial that compared early and late Treat\u2010and\u2010Extend for 2\u2009years. Refracted ETDRS best corrected visual acuity (BCVA), central retinal thickness (CRT), treatment interval and adverse events were assessed. Quality\u2010of\u2010life was measured using the Macular Disease Dependent Quality of Life (MacDQoL) and Macular Disease Treatment Satisfaction Questionnaires (MacTSQ).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010six of 40 participants completing the MATE\u2010trial were enrolled with 20 completing the total 4\u2010year study. Mean BCVA was 60.7 at Month 0 and 64.8 ETDRS letters at Month 48 while CRT decreased from 423.7\u2009\u03bcm to 292.2\u2009\u03bcm. Five participants discontinued treatment due to inactivity. The mean number of treatments and visits for the remaining participants was 27 and 30.0, respectively, with treatment intervals extended to 12\u2009weeks in four participants at Month 48. Both AMD\u2010specific QoL and treatment satisfaction remained stable between Months 0 and 48 and mean BCVA significantly correlated with AMD\u2010specific QoL scores at Months 12, 24 and 48.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Results suggest that BCVA can be maintained over 48\u2009months when following a treat\u2010extend\u2010and\u2010fix regimen of aflibercept with intervals out to 12\u2009weeks, while maintaining AMD\u2010specific QoL and treatment satisfaction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.15774","type":"journal-article","created":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T07:10:45Z","timestamp":1696057845000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Treatment of age\u2010related macular degeneration with aflibercept using a treat, extend and fixed protocol; A 4\u2010year study of treatment outcomes, durability, safety and quality of life (An extension to the <scp>MATE<\/scp> randomised controlled trial)"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1856-802X","authenticated-orcid":false,"given":"Archana","family":"Airody","sequence":"first","affiliation":[{"name":"Academic Unit of Ophthalmology York and Scarborough Teaching Hospitals NHS Foundation Trust  York UK"},{"name":"Hull York Medical School University of York  York UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi A.","family":"Baseler","sequence":"additional","affiliation":[{"name":"Hull York Medical School University of York  York UK"},{"name":"Department of Psychology University of York  York UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Seymour","sequence":"additional","affiliation":[{"name":"Hull York Medical School University of Hull  Hull UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Allgar","sequence":"additional","affiliation":[{"name":"Peninsula Medical School University of Plymouth  Plymouth UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajarshi","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Leeds Teaching Hospital NHS Foundation Trust  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Downey","sequence":"additional","affiliation":[{"name":"Hull and East Yorkshire NHS Trust  Hull UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushma","family":"Dhar\u2010Munshi","sequence":"additional","affiliation":[{"name":"Kings Mill Hospital Sherwood Forest Hospitals NHS Foundation Trust  Sutton\u2010in\u2010Ashfield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajjad","family":"Mahmood","sequence":"additional","affiliation":[{"name":"University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Balaskas","sequence":"additional","affiliation":[{"name":"University of Manchester  Manchester UK"},{"name":"NIHR Moorfields Biomedical Research Centre Moorfields Eye Hospital NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theo","family":"Empeslidis","sequence":"additional","affiliation":[{"name":"Leicester Royal Infirmary University Hospitals of Leicester NHS Trust  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel L. 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