{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T06:13:35Z","timestamp":1769753615314,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:00:00Z","timestamp":1696896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To examine relationships between mesopic visual sensitivity measurements on microperimetry and macular inner and outer retinal layer (IRL and ORL) thicknesses in healthy younger, middle\u2010aged and older subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 154 healthy adults were divided into three age groups each with similar mean sensitivity. Regional retinal sensitivity (determined by mesopic fundus\u2010controlled microperimetry) and IRL (ganglion cell\u2010related layer) and ORL thicknesses were measured in the five subfields: central fovea (1\u2009mm diameter) and the quadrants temporal, nasal, superior and inferior of a parafoveal ring of outer diameter 3\u2009mm and inner diameter 1\u2009mm. Relationships between regional sensitivity and corresponding IRL and ORL thicknesses were assessed through a univariate and multivariate linear regression model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Visual sensitivity means for each subfield differed across age groups (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In each parafoveal ring quadrant, mean IRL thickness was reduced in the older eyes compared to the other groups (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). In the inferior region, worse sensitivity was correlated with greater IRL thickness (<jats:italic>p<\/jats:italic>\u2009=\u20090.0207) in the middle\u2010aged group and with a thicker ORL (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and thinner IRL (<jats:italic>p<\/jats:italic>\u2009=\u20090.0003) in the older eyes (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.51). The slopes of regression lines relating sensitivity to IRL thickness and age group (<jats:italic>p<\/jats:italic>\u2009=\u20090.0027) or to ORL thickness and age group (<jats:italic>p<\/jats:italic>\u2009=\u20090.0020) differed significantly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The relationship observed between mesopic visual sensitivity and retinal layer thickness varied with age. A worse sensitivity was related to a thicker macular IRL layer in middle\u2010aged eyes and to a thicker ORL and thinner IRL in older eyes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.15790","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T04:50:45Z","timestamp":1697086245000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Relationships between mesopic visual sensitivity and macular inner and outer retinal layer thickness in healthy younger, middle\u2010aged and older adults"],"prefix":"10.1111","volume":"102","author":[{"given":"Juan E.","family":"Cedr\u00fan\u2010S\u00e1nchez","sequence":"first","affiliation":[{"name":"Applied Vision Research Group, Department of Optometry and Vision Science, Faculty of Optics and Optometry Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Moreira\u2010Estebaranz","sequence":"additional","affiliation":[{"name":"Applied Vision Research Group, Department of Optometry and Vision Science, Faculty of Optics and Optometry Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melisa","family":"Remis\u2010Gonzalez","sequence":"additional","affiliation":[{"name":"Applied Vision Research Group, Department of Optometry and Vision Science, Faculty of Optics and Optometry Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9227-4927","authenticated-orcid":false,"given":"Mar\u00eda C.","family":"Puell","sequence":"additional","affiliation":[{"name":"Applied Vision Research Group, Department of Optometry and Vision Science, Faculty of Optics and Optometry Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S137223"},{"key":"e_1_2_6_3_1","first-page":"403","article-title":"Aging and vision: changes in function and performance from optics to perception. 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