{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T03:24:04Z","timestamp":1788319444918,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:00:00Z","timestamp":1698105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008397","name":"Velux Fonden","doi-asserted-by":"publisher","award":["00051094"],"award-info":[{"award-number":["00051094"]}],"id":[{"id":"10.13039\/100008397","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The aim of this study was to investigate retinal vein occlusion (RVO) as an independent marker of incident dementia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a prospective nationwide cohort study, we identified 2\u2009225\u2009568 individuals through the Danish national health registers. Individuals older than 65\u2009years, without unspecified retinal vascular occlusion or dementia were included from 1998 to 2020 and followed until 2022. We calculated the incidence rate (IR) and performed a Cox regression analysis with a hazard ratio (HR) and 95% confidence interval (CI) for RVO (exposure) as a marker of all\u2010cause dementia adjusted for systemic comorbidity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 19\u2009669 individuals with RVO who had a higher prevalence of systemic comorbidity at inclusion compared to those without RVO (<jats:italic>n<\/jats:italic>\u2009=\u20092\u2009185\u2009483). We performed a Cox regression analysis for age\u2010dependent exposure due to non\u2010proportional hazards in the pre\u2010planned analysis. Exposed individuals younger than 75\u2009years had an increased risk of all\u2010cause dementia (adjusted HR 1.09, 95% CI 1.01\u20131.18), whereas individuals older than 75\u2009years had a decreased risk of all\u2010cause dementia (adjusted HR 0.92, 95% CI 0.86\u20130.98).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Individuals with RVO had an age\u2010dependent risk of dementia, with a 9% increased risk in individuals with RVO younger than 75\u2009years and an 8% decreased risk in individuals older than 75\u2009years at the time of exposure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.15797","type":"journal-article","created":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T14:19:45Z","timestamp":1698157185000},"page":"455-461","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Retinal vein occlusion as an age\u2010dependent marker of incident dementia in a long\u2010term Danish national cohort"],"prefix":"10.1111","volume":"102","author":[{"given":"Anna Rebien","family":"Clausen","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Odense University Hospital  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lonny","family":"Stokholm","sequence":"additional","affiliation":[{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"},{"name":"OPEN\u2014Open Patient data Explorative Network Odense University Hospital and University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrine Hartmund","family":"Frederiksen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f6ren","family":"M\u00f6ller","sequence":"additional","affiliation":[{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"},{"name":"OPEN\u2014Open Patient data Explorative Network Odense University Hospital and University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Blaabjerg","sequence":"additional","affiliation":[{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"},{"name":"Department of Neurology Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik N\u00f8rregaard","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Odense University Hospital  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5019-0736","authenticated-orcid":false,"given":"Jakob","family":"Grauslund","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Odense University Hospital  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense 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