{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T06:07:25Z","timestamp":1776492445873,"version":"3.51.2"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate whether cooled anaesthetic eyedrops and antiseptics alleviate pain and minimise subconjunctival haemorrhage following intravitreal injection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective, double\u2010masked, randomised controlled trial of 100 participants receiving either cooled (<jats:italic>n<\/jats:italic>\u2009=\u200950) or room temperature (<jats:italic>n<\/jats:italic>\u2009=\u200950) topical anaesthetic eyedrops and antiseptics before receiving an injection of bevacizumab. Baseline tolerability was estimated using a self\u2010reported pain sensitivity questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall tolerability was comparable between the study group and the control group (0.75\u2009\u00b1\u20090.13 vs. 0.74\u2009\u00b1\u20090.14, respectively, <jats:italic>p<\/jats:italic>\u2009=\u20090.99). Subconjunctival haemorrhage incidence was similar in both groups (80% vs. 86%, respectively, <jats:italic>p<\/jats:italic>\u2009=\u20090.113), as was subconjunctival haemorrhage size (2.75\u2009\u00b1\u20095.51\u2009mm<jats:sup>2<\/jats:sup> vs. 5.53\u2009\u00b1\u200910.72\u2009mm<jats:sup>2<\/jats:sup>, respectively, <jats:italic>p<\/jats:italic>\u2009=\u20090.11). Sub\u2010group analysis demonstrated that the participants taking daily ocular eyedrops who received cooled anaesthetic eyedrops and antiseptics reported less pain at 10\u2009min and less burning sensation at 24\u2009h compared with matched controls (0.67\u2009\u00b1\u20091.50 vs. 2.50\u2009\u00b1\u20093.03, respectively, <jats:italic>p<\/jats:italic>\u2009=\u20090.040 and 0.00\u2009\u00b1\u20090.00 vs. 1.44\u2009\u00b1\u20092.96, respectively, <jats:italic>p<\/jats:italic>\u2009=\u20090.045). Participants who received cooled eyedrops and did not use antithrombotic therapy had smaller\u2010sized subconjunctival haemorrhages compared with matched controls (1.55\u2009\u00b1\u20091.87\u2009mm<jats:sup>2<\/jats:sup> vs. 8.29\u2009\u00b1\u200914.61\u2009mm<jats:sup>2<\/jats:sup>, respectively, <jats:italic>p<\/jats:italic>\u2009=\u20090.038). Participants with hypertension who received cooled eyedrops had smaller\u2010sized subconjunctival haemorrhage compared with matched controls (2.33\u2009\u00b1\u20094.99\u2009mm<jats:sup>2<\/jats:sup> vs. 6.89\u2009\u00b1\u200912.41\u2009mm<jats:sup>2<\/jats:sup>, respectively, <jats:italic>p<\/jats:italic>\u2009=\u20090.045).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The benefit of using cooled anaesthetic eyedrops and antiseptics to alleviate pain and minimise subconjunctival haemorrhage following intravitreal injection was not proven in the general population. It may be beneficial in part for some patients, such as those who regularly use eyedrops, patients with hypertension or those not on antithrombotic therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.15798","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T05:45:16Z","timestamp":1697694316000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pain control and subconjunctival haemorrhage after intravitreal injection using cooled anaesthetic eyedrops and antiseptics: A prospective, double\u2010blind, randomized controlled trial"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0691-9862","authenticated-orcid":false,"given":"Ran","family":"Moshkovsky","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Wolfson Medical Center  Holon Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv 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