{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:43:03Z","timestamp":1790228583721,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the safety and efficacy of intravitreal injections of 0.5\u2009mg conbercept in patients with choroidal neovascularization secondary to pathological myopia (pmCNV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The 177 pmCNV patients were randomly assigned in a 3:1 ratio to receive conbercept or sham injection, respectively. The conbercept group receive conbercept intravitreal injections administered on a pro re nata (PRN) basis after 3 monthly loading doses. The sham group received three consecutive monthly sham injections and then one conbercept injection followed by PRN conbercept intravitreal injections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At month 3, the mean BCVA for the two groups were improved by 12.0 letters (conbercept group, from 54.05 letters to 66.05 letters) and 0.6 letters (sham group, from 49.77 letters to 50.33 letters), respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The mean central retinal thickness (CRT) at month 3 in the two groups decreased 62.0\u2009\u03bcm (conbercept group, from 348.90\u2009\u03bcm to 286.18\u2009\u03bcm) and 4.4\u2009\u03bcm (sham group, from 347.86\u2009\u03bcm to 343.47\u2009\u03bcm) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). At month 9, the mean BCVA improved by 13.3 letters in the conbercept group and 11.3 letters in the sham group. The mean CRT decreased 73.6\u2009\u03bcm in the conbercept group and 55.9\u2009\u03bcm in the sham group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The most common ocular adverse events were associated with intravitreal injections, such as conjunctival haemorrhage and increased intraocular pressure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Intravitreal injections of 0.5\u2009mg conbercept provided improvement in visual and anatomical outcomes in pmCNV patients with low rates of ocular and nonocular safety events.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.15810","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T23:06:13Z","timestamp":1701126373000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Safety and efficacy of intravitreal injection of conbercept for the treatment of patients with choroidal neovascularization secondary to pathological myopia: Results from the <scp>SHINY<\/scp> 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