{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T13:10:09Z","timestamp":1765113009292,"version":"3.40.5"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81900899","82070994"],"award-info":[{"award-number":["81900899","82070994"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the effect of COVID\u201019 home confinement on the efficacy of the interventions for controlling myopia, and to select effective therapies to control myopia during COVID\u201019 confinement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Children (<jats:italic>n<\/jats:italic>\u2009=\u2009164) aged 8\u201312\u2009years with spherical equivalent refraction of \u22121.00 to \u22126.00 diopters were stratified into two age subgroups and randomly allocated into the control, 0.01% atropine, orthokeratology (ortho\u2010k) and atropine combined ortho\u2010k (ACO) groups. Axial length (AL) was measured at baseline, 6\u2010, 12\u2010, 18\u2010 and 24\u2010month visits. The follow\u2010up spanned the period before the COVID\u201019 outbreak, the period of the home confinement, and the period of the school reopening. Hence, the AL change in different periods was collected and compared. Data analysis was performed following the criteria of intention to treat (ITT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All 164 children were involved in the ITT analysis. Compared to control, all interventions can still reduce the AL elongation during the COVID\u201019 home confinement period (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). However, the efficacy was compromised: individuals experienced more AL elongation during the COVID\u201019 home confinement period in the control, 0.01% atropine and ACO groups (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Interestingly, in the ortho\u2010k group, the difference was insignificant (<jats:italic>p<\/jats:italic>\u2009=\u20090.178), and the interaction between the intervention type (control vs. ortho\u2010k) and the confinement severity was significant (<jats:italic>p<\/jats:italic> for interaction\u2009=\u20090.041), which is different from the atropine (<jats:italic>p<\/jats:italic> for interaction\u2009=\u20090.248) or ACO group (<jats:italic>p<\/jats:italic> for interaction\u2009=\u20090.988). These results were stable after being adjusted by other variables based on the multivariable regression model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ortho\u2010k was less affected by the COVID\u201019 home confinement, which is potentially a better therapy for children in this high\u2010risk environment. Further investigations are warranted to validate this issue.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.15818","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T21:44:53Z","timestamp":1700603093000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of <scp>COVID<\/scp>\u201019 home confinement on the efficacy of orthokeratology, 0.01% atropine and combined treatment"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4349-6507","authenticated-orcid":false,"given":"Shengsong","family":"Xu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinyun","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic 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