{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T10:55:35Z","timestamp":1793271335490,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,12,23]],"date-time":"2023-12-23T00:00:00Z","timestamp":1703289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010328","name":"Stichting Lijf en Leven","doi-asserted-by":"publisher","award":["L&L\/mon\/19\u2010007"],"award-info":[{"award-number":["L&L\/mon\/19\u2010007"]}],"id":[{"id":"10.13039\/501100010328","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To determine the thickness of the conjunctiva, episclera and sclera in healthy individuals using anterior segment optical coherence tomography (AS\u2010OCT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively included 107 healthy individuals of different age groups (18\u201339\u2009years, 40\u201354\u2009years, 55\u201369\u2009years and \u226570\u2009years). For each eye, AS\u2010OCT scans of four quadrants (temporal, nasal, superior and inferior) were acquired. The thickness of the conjunctiva, episclera and sclera was measured for each scan. In addition, the axial length of both eyes was measured, and general characteristics, including smoking, allergies and contact lens use, were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean conjunctival thickness was significantly different between the nasal and superior quadrants (87\u2009\u00b1\u200930\u2009\u03bcm vs. 77\u2009\u00b1\u200916\u2009\u03bcm; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), as well as the superior and inferior quadrants (77\u2009\u00b1\u200916\u2009\u03bcm vs. 86\u2009\u00b1\u200919\u2009\u03bcm; <jats:italic>p<\/jats:italic>\u2009=\u20090.001). The mean episcleral thickness was larger in the superior (174\u2009\u00b1\u200954\u2009\u03bcm) and inferior (141\u2009\u00b1\u200943\u2009\u03bcm) quadrants, compared to the nasal (83\u2009\u00b1\u200938\u2009\u03bcm) and temporal quadrants (90\u2009\u00b1\u200944\u2009\u03bcm). The mean scleral thickness of the inferior quadrant was the largest (596\u2009\u00b1\u200964\u2009\u03bcm), followed by the nasal (567\u2009\u00b1\u200976\u2009\u03bcm), temporal (516\u2009\u00b1\u200967\u2009\u03bcm) and superior (467\u2009\u00b1\u200952\u2009\u03bcm) quadrants (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The averaged scleral thickness increased 0.96\u2009\u03bcm per age year (0.41\u20131.47\u2009\u03bcm, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study provides an assessment of the thickness of scleral and adjacent superficial layers in healthy individuals determined on AS\u2010OCT, which could enable future research into the use of AS\u2010OCT in diseases affecting the anterior eye wall.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.16606","type":"journal-article","created":{"date-parts":[[2023,12,23]],"date-time":"2023-12-23T08:25:45Z","timestamp":1703319945000},"page":"573-580","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Assessment of conjunctival, episcleral and scleral thickness in healthy individuals using anterior segment optical coherence tomography"],"prefix":"10.1111","volume":"102","author":[{"given":"G. J.","family":"Teeuw","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Erasmus MC, University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3872-1431","authenticated-orcid":false,"given":"D. P. C.","family":"Vergouwen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Erasmus MC, University Medical Center Rotterdam  Rotterdam The Netherlands"},{"name":"Department of Immunology Erasmus MC, University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1780-5281","authenticated-orcid":false,"given":"W. D.","family":"Ramdas","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Erasmus MC, University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4061-4846","authenticated-orcid":false,"given":"L.","family":"Sanchez\u2010Brea","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Erasmus MC, University Medical Center Rotterdam  Rotterdam The Netherlands"},{"name":"Department of Radiology &amp; Nuclear Medicine Erasmus MC, University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Andrade\u00a0De\u00a0Jesus","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Erasmus MC, University Medical Center Rotterdam  Rotterdam The Netherlands"},{"name":"Department of Radiology &amp; Nuclear Medicine Erasmus MC, University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3324-5034","authenticated-orcid":false,"given":"A.","family":"Rothova","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Erasmus MC, University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. R.","family":"Vingerling","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Erasmus MC, University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4610-4991","authenticated-orcid":false,"given":"J. 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