{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T23:18:12Z","timestamp":1793229492063,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004286","name":"Santen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004286","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Bleb failure is a common complication after glaucoma filtration surgery. Different bleb classification schemes incorporating filtration bleb vascularization have been proposed, but the reported correlation with intraocular pressure (IOP) has been variable, possibly because of subjective vascularization grading. The purpose of the present study was to evaluate bleb vascularization after Preserflo Microshunt (PM) implantation using anterior segment OCT\u2010angiography (AS\u2010OCTA) as a biomarker for bleb failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010three eyes of twenty\u2010three patients underwent PM implantation. Up to 12\u2009months after surgery PM scleral passage\u2010centred AS\u2010OCTA measurements (PLEX Elite 9000) for bleb\u2010vessel density (BVD) determination were performed and IOP as well as necessity for surgical revisions (needling and open revision) were documented. After multi\u2010step image analysis (region of interest definition, artefact removal, binarization, BVD calculation), the predictive value of early postoperative BVD for surgical revisions was assessed using logistic regression modelling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline IOP (23.57\u2009\u00b1\u20097.75\u2009mmHg) decreased significantly to 8.30\u2009\u00b1\u20092.12, 9.17\u2009\u00b1\u20092.33 and 11.70\u2009\u00b1\u20094.40\u2009mmHg after 1, 2 and 4\u2009week(s), and 13.48\u2009\u00b1\u20095.83, 11.87\u2009\u00b1\u20094.49, 12.30\u2009\u00b1\u20096.65, 11.87\u2009\u00b1\u20093.11 and 13.05\u2009\u00b1\u20094.12\u2009mmHg after 2, 3, 6, 9 and 12\u2009month(s), respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Nine patients (39%) needed surgical revisions after a median time of 2\u2009months. Bleb vessel densities at 2 and 4\u2009weeks were significantly associated with future surgical revisions upon logistic regression analysis (2\u2009W\/4\u2009W likelihood\u2010ratio test <jats:italic>p<\/jats:italic>\u2010value: 0.0244\/0.0098; 2\u2009W\/4\u2009W area under the receiver operating characteristics curve: 0.796\/0.909).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Filtration bleb vessel density can be determined using AS\u2010OCTA in the early postoperative period and is predictive for bleb failure after PM implantation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.16642","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T16:22:15Z","timestamp":1706890935000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Bleb vessel density as a predictive factor for surgical revisions after Preserflo Microshunt implantation"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2792-6925","authenticated-orcid":false,"given":"Sophie","family":"Schneider","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Optometry, Kepler University Hospital Johannes Kepler University  Linz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Kallab","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Optometry, Kepler University Hospital Johannes Kepler University  Linz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Murauer","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Optometry, Kepler University Hospital Johannes Kepler University  Linz 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