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On retinal photographs, we defined central drusen as at least one soft drusen (&gt;63\u2009\u03bcm) within 500\u2009\u03bcm from fovea and pericentral drusen as at least one drusen 500\u20133000\u2009\u03bcm from fovea, in the absence of any central drusen. Late AMD (atrophic and\/or neovascular) was diagnosed using multimodal imaging. In total, 481 eyes were included in the analysis: 160 central and 321 pericentral. We investigated associations with systemic (age, sex, smoking, medical prescriptions, plasma concentrations of lipids and nutrients, UV exposure, blood pressure), ocular (retinal thickness, cataract extraction) and genetic risk scores (GRS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In multivariate logistic regression central drusen were associated with smoking (OR, 2.95 for smoking more than 20 pack\u2010years, <jats:italic>p<\/jats:italic>\u2009=\u20090.02), HDL\u2010cholesterol (OR, 1.57 for 1 standard deviation (SD) increase, <jats:italic>p<\/jats:italic>\u2009=\u20090.0048), pulse pressure (OR, 0.77 for 1 SD increase, <jats:italic>p<\/jats:italic>\u2009=\u20090.04), Age\u2010Related Maculopathy Susceptibility 2 (ARMS2) GRS (OR, 1.42; 95% CI, 1.11\u20131.83) and complement GRS (OR, 1.55; 95% CI, 1.15\u20132.10). In Cox modelling, the central location of drusen (at baseline or during the follow\u2010up) was associated with a 4.41\u2010fold increased risk (95% CI,1.98\u20139.81) for an incident late AMD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Central drusen were strongly associated with AMD risk factors and incident late AMD, suggesting that it represents a key marker for AMD progression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.16645","type":"journal-article","created":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T03:43:50Z","timestamp":1706327030000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Associations of drusen location with risk factors and incidence of late <scp>age\u2010related<\/scp> macular degeneration in the <scp>Alienor<\/scp> 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