{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T01:35:23Z","timestamp":1785202523536,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T00:00:00Z","timestamp":1707609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T00:00:00Z","timestamp":1707609600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008564","name":"Norges Blindeforbund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Women with hypertensive disorders of pregnancy (HDP) are at increased risk of developing premature cardiovascular disease (CVD). The mechanisms behind this are not fully understood, but microvascular alterations have been documented in retinal arterioles and venules. The aim of this study was to use non\u2010invasive retinal imaging to investigate the structural and functional properties of arterioles, venules and capillaries in this patient group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We examined 27 women with previous HDP and 23 controls at 3\u2009years postpartum. The retinal microvasculature was assessed by vessel calibre measurements, retinal oximetry and optical coherence tomography angiography. Differences were analysed using non\u2010parametric tests and multiple regression analyses, adjusted for age and body mass index.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median arteriolar oxygen saturation (SaO\n                      <jats:sub>2<\/jats:sub>\n                      ; 94.2% vs. 93.0%), venular oxygen saturation (SvO\n                      <jats:sub>2<\/jats:sub>\n                      ; 60.1% vs. 62.4%) and arteriovenous saturation difference (AV\u2010difference; 32.8% vs. 32.3%) were similar across groups. Capillary vessel density (VD; 46.2% vs. 46.3%), skeletonised VD (VSD; 21.3 vs. 21.1\u2009mm\/mm\n                      <jats:sup>2<\/jats:sup>\n                      ) and vessel diameter index (21.65 vs. 21.86) were also comparable. In the HDP group, mean arterial pressure (MAP) was positively correlated with AV\u2010difference (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.209) and negatively correlated with arteriolar diameter (CRAE;\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.382).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Structural microvascular alterations appear not to be key biomarkers for CVD risk after HDP as early as 3\u2009years postpartum in otherwise healthy women. Further studies are needed to evaluate whether such changes occur later in life. MAP was associated with AV\u2010difference only in the HDP group, suggesting specific mechanisms affecting functional microvascular properties in these women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.16651","type":"journal-article","created":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T23:09:11Z","timestamp":1707692951000},"page":"653-661","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Retinal oximetry and microvascular assessment after hypertensive pregnancy complications"],"prefix":"10.1111","volume":"102","author":[{"given":"Sissel","family":"Hoel","sequence":"first","affiliation":[{"name":"Institute of Clinical Medicine, Faculty of Medicine University of Oslo  Oslo Norway"},{"name":"Division of Obstetrics and Gynaecology Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjartan","family":"Moe","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, Faculty of Medicine University of Oslo  Oslo Norway"},{"name":"Division of Obstetrics and Gynaecology Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meryam","family":"Sugulle","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, Faculty of Medicine University of Oslo  Oslo Norway"},{"name":"Division of Obstetrics and Gynaecology Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2905-9252","authenticated-orcid":false,"given":"Goran","family":"Petrovski","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, Faculty of Medicine University of Oslo  Oslo Norway"},{"name":"Department of Ophthalmology, Center for Eye Research and Innovative Diagnostics Oslo University Hospital  Oslo Norway"},{"name":"Department of Ophthalmology University of Split School of Medicine and University Hospital Centre  Split Croatia"},{"name":"UKLONetwork University St. Kliment Ohridski\u2014Bitola  Bitola North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina Charlotte B. B.","family":"Veiby","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Center for Eye Research and Innovative Diagnostics Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Cathrine","family":"Staff","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, Faculty of Medicine University of Oslo  Oslo Norway"},{"name":"Division of Obstetrics and Gynaecology Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.3.5.2"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.036632"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-017-0917-2"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.10803"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-019-0531-y"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32836586f4"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.22336\/rjo.2017.32"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13932"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2015.07.007"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-9912"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0643-8"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2009.94"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-0039"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-7-200910060-00010"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016340600569133"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1076\/ceyr.27.3.143.16049"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000307"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2021.100951"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.023005"},{"key":"e_1_2_9_21_1","unstructured":"Lindberg M. Hov G.G. Hardang I.&Monsen A.\u2010L.B.(2022)Nasjonal Brukerh\u00e5ndbok i Medisinsk Biokjemi."},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.10964"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000003538"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10504"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14696"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753495X17745727"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2019.07.004"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2012.11.022"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2013.09.001"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.06357"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-21776"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2019.04.001"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-7275"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8849116"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14462"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.15018"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab484"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00684-X"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.9.1153"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-1313.2005.00288.x"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc4301.098254"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.16651","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aos.16651","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.16651","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:12:41Z","timestamp":1772989961000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.16651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,11]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/aos.16651"],"URL":"https:\/\/doi.org\/10.1111\/aos.16651","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,11]]},"assertion":[{"value":"2023-09-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}