{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:57:58Z","timestamp":1792684678757,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    To compare the safety and efficacy of the Preserflo Microshunt with trabeculectomy in the treatment of patients with glaucoma. A systematic review and meta\u2010analysis was conducted. The primary outcome measures recorded as a measure of efficacy of the interventions were intra\u2010ocular pressure (IOP) at final follow\u2010up and IOP reduction (IOPR). Secondary outcomes recorded to measure efficacy were reduction in the number of glaucoma medications and reinterventions. To assess safety profile, the proportions of patients with post\u2010operative complications were recorded. Seven articles were included in this study. A total of 1353 eyes were included in this review (Preserflo: 812, trabeculectomy: 541). Post\u2010operative IOP (mean difference [MD]\u2009=\u20090.78 [0.66, 0.90],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) results are significantly lower for trabeculectomy than Preserflo. The IOPR (MD\u2009=\u2009\u22121.20 [\u22122.30, \u22120.09],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.034) results significantly favour trabeculectomy over Preserflo Microshunt. The reduction in topical glaucoma medications (MD\u2009=\u2009\u22120.32 [\u22120.58, \u22120.07],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.014) is significantly higher for trabeculectomy. There is no statistically significant difference in levels of hypotony (risk ratio [RR]\u2009=\u2009\u22120.05 [\u22120.47, 0.37],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.806), choroidal effusion\/detachment (RR\u2009=\u2009\u22120.12 [\u22120.42, 0.19],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.444), hyphaema (RR\u2009=\u20090.20 [\u22120.11, 0.51],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.216) and flat anterior chamber (RR\u2009=\u20090.49 [\u22121.02, 0.03],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.066). There are significantly more bleb\u2010related complications in the trabeculectomy groups than Preserflo groups (RR\u2009=\u2009\u22120.63 [\u22121.01, \u22120.24],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001). There were statistically more reinterventions required in the trabeculectomy groups than Preserflo groups (RR\u2009=\u2009\u22120.48 [\u22120.65, \u22120.30],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Compared to trabeculectomy, the Preserflo Microshunt is not as effective in lowering intra\u2010ocular pressure, has a similar safety profile and has a lower reintervention rate. Further research is required given the lack of randomised controlled trials within this study and resulting low strength of evidence.\n                  <\/jats:p>","DOI":"10.1111\/aos.16658","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T08:22:07Z","timestamp":1708417327000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Comparing the safety and efficacy of Preserflo Microshunt implantation and trabeculectomy for glaucoma: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2642-1776","authenticated-orcid":false,"given":"Adan","family":"Khan","sequence":"first","affiliation":[{"name":"Discipline of Surgery, School of Medicine Clinical Science Institute, National University of Ireland  Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attam Ullah","family":"Khan","sequence":"additional","affiliation":[{"name":"Discipline of Surgery, School of Medicine Clinical Science Institute, National University of Ireland  Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,20]]},"reference":[{"key":"e_1_2_9_2_1","article-title":"Epidemiology of glaucoma: the past, present, and predictions for the future","volume":"12","author":"Allison K.","year":"2020","journal-title":"Cureus"},{"key":"e_1_2_9_3_1","unstructured":"Aref A.A.&Elhusseiny A.M.(2022)PreserFlo Ab\u2010externo Microshunt. Eye Wiki.https:\/\/eyewiki.aao.org\/Preserflo_Ab\u2010Externo_Microshunt. Accessed 15 June 2023."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3928\/15428877-20110603-01"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2022.05.016"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2021.05.023"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000001734"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000000368"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogla.2021.07.008"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2307\/2533446"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-022-02230-1"},{"key":"e_1_2_9_12_1","unstructured":"Durr G.M.(2020)Preserflo MicroShunt.Glaucoma Today: The Pipeline."},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_9_14_1","article-title":"An independent GLP evaluation of a new glaucoma drain, the Midi","volume":"47","author":"Fantes F.","year":"2006","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_9_15_1","article-title":"PreserFlo\u2122 MicroShunt versus trabeculectomy in patients with moderate to advanced open\u2010angele glaucoma: 12\u2010month follow\u2010up of a single\u2010center prospective study","volume":"14","author":"Fili S.","year":"2022","journal-title":"Cureus Journal of Medical Science"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11185481"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.10.9.9"},{"key":"e_1_2_9_18_1","unstructured":"Ga Wells B.S. D O'connell J. Peterson V.W. Losos M.&Tugwell P.(2021)Newcastle\u2010Ottawa scale. Ottawa Hospital Research Institute.https:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp. Accessed 29 June 2023."},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-5-13"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-023-06075-4"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-022-02326-6"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2022-065921"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11237086"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12083000"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.09.004"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.09.041"},{"key":"e_1_2_9_28_1","unstructured":"Sarwat Salim F. Piltz\u2010Seymour J. Siegfried C.J.&Sheybani A.(2023)Trabeculectomy. Eye Wiki.https:\/\/eyewiki.aao.org\/Trabeculectomy. Accessed 17 June 2023."},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.05.013"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogla.2022.11.006"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.3102\/10769986030003261"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.15042"},{"key":"e_1_2_9_33_1","article-title":"Intra\u2010operative mitomycin C for glaucoma surgery","volume":"2005","author":"Wilkins M.","year":"2005","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.16658","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T23:24:31Z","timestamp":1718061871000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.16658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,20]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/aos.16658"],"URL":"https:\/\/doi.org\/10.1111\/aos.16658","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,20]]},"assertion":[{"value":"2023-10-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}