{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:08:18Z","timestamp":1791461298872,"version":"4.3.4"},"reference-count":379,"publisher":"Wiley","issue":"S282","license":[{"start":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T00:00:00Z","timestamp":1710115200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Age\u2010related macular degeneration (AMD) is a devastating eye disease that causes permanent vision loss in the central part of the retina, known as the macula. Patients with such severe visual loss face a reduced quality of life and are at a 1.5 times greater risk of death compared to the general population. Currently, there is no cure for or effective treatment for dry AMD. There are several mechanisms thought to underlie the disease, for example, ageing\u2010associated chronic oxidative stress, mitochondrial damage, harmful protein aggregation and inflammation. As a way of gaining a better understanding of the molecular mechanisms behind AMD and thus developing new therapies, we have created a peroxisome proliferator\u2010activated receptor gamma coactivator 1\u2010alpha and nuclear factor erythroid 2\u2010related factor 2 (\n                    <jats:italic>PGC1\u03b1<\/jats:italic>\n                    \/\n                    <jats:italic>NFE2L2<\/jats:italic>\n                    ) double\u2010knockout (dKO) mouse model that mimics many of the clinical features of dry AMD, including elevated levels of oxidative stress markers, damaged mitochondria, accumulating lysosomal lipofuscin and extracellular drusen\u2010like structures in retinal pigment epithelial cells (RPE). In addition, a human RPE cell\u2010based model was established to examine the impact of non\u2010functional intracellular clearance systems on inflammasome activation. In this study, we found that there was a disturbance in the autolysosomal machinery responsible for clearing mitochondria in the RPE cells of one\u2010year\u2010old PGC1\u03b1\/NFE2L2\u2010deficient mice. The confocal immunohistochemical analysis revealed an increase in autophagosome marker microtubule\u2010associated proteins 1A\/1B light chain 3B (LC3B) as well as multiple mitophagy markers such as PTE\u2010induced putative kinase 1 (PINK1) and E3 ubiquitin ligase (PARKIN), along with signs of damaged mitochondria. However, no increase in autolysosome formation was detected, nor was there a colocalization of the lysosomal marker LAMP2 or the mitochondrial marker, ATP synthase \u03b2. There was an upregulation of late autolysosomal fusion Ras\u2010related protein (Rab7) in the perinuclear space of RPE cells, together with autofluorescent aggregates. Additionally, we observed an increase in the numbers of Toll\u2010like receptors 3 and 9, while those of NOD\u2010like receptor 3 were decreased in PGC1\u03b1\/NFE2L2 dKO retinal specimens compared to wild\u2010type animals. There was a trend towards increased complement component C5a and increased involvement of the serine protease enzyme, thrombin, in enhancing the terminal pathway producing C5a, independent of C3. The levels of primary acute phase C\u2010reactive protein and receptor for advanced glycation end products were also increased in the PGC1\u03b1\/NFE2L2 dKO retina. Furthermore, selective proteasome inhibition with epoxomicin promoted both nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and mitochondrial\u2010mediated oxidative stress, leading to the release of mitochondrial DNA to the cytosol, resulting in potassium efflux\u2010dependent activation of the absent in melanoma 2 (AIM2) inflammasome and the subsequent secretion of interleukin\u20101\u03b2 in ARPE\u201019 cells. In conclusion, the data suggest that there is at least a relative decrease in mitophagy, increases in the amounts of C5 and thrombin and decreased C3 levels in this dry AMD\u2010like model. Moreover, selective proteasome inhibition evoked mitochondrial damage and AIM2 inflammasome activation in ARPE\u201019 cells.\n                  <\/jats:p>","DOI":"10.1111\/aos.16661","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T00:10:45Z","timestamp":1710202245000},"page":"3-53","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Mitochondrial damage and clearance in retinal pigment epithelial cells"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1863-9550","authenticated-orcid":false,"given":"Iswariyaraja Sridevi","family":"Gurubaran","sequence":"first","affiliation":[{"name":"Department of Medicine, Clinical Medicine Unit University of Eastern Finland Institute of Clinical Medicine  Kuopio Northern Savonia Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7901270"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1391"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/10715762.2018.1468564"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00169"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903678"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02379"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706182"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201444560"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010021\u201003796\u20109"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102013\u201005\u2010502229"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/360438"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2013.04.006"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901363"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spen.2019.05.006"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03\u20100289fje"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2070"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201899916"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2022.109170"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2010.199216"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001721\u2010200010000\u201000006"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20010210"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.1993.supplement_17.27"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2012.11.002"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2001.141"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.170007"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.21769\/BioProtoc.1839"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101201"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2271"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20081370"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026\u2010012\u20108270\u20101"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm4010172"},{"key":"e_1_2_9_33_1","first-page":"27","article-title":"Oxidative stress and inflammation in the development of cardiovascular disease and contrast induced nephropathy","volume":"4","author":"Cervantes\u2010Gracia K.","year":"2020","journal-title":"Vessel Plus"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.4172\/2376\u20100427.1000227"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417\u2010010\u20101568\u20106"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00200"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2011.12.039"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B2000808"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01487"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201002108"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00539"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201061805\u20106"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201004593\u2010w"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2837"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22115898"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3249"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.11613\/bm.2012.005"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.06.013"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.12224"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2005.09.005"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1403068"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M608083200"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2019.101341"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/646354"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00430.2012"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.181.6.2119"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.02000"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0103604"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2017.03.002"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2014.05.008"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.06.020"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/0968\u20100004(90)90019\u20108"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471\u20104159.2001.00302.x"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1515\/hsz\u20102012\u20100119"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep01077"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.04.036"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2007.07.006"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2015.1009776"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002001"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1134\/s1607672909020112"},{"issue":"8","key":"e_1_2_9_71_1","first-page":"1691","article-title":"Cell loss in the aging retina. Relationship to lipofuscin accumulation and macular degeneration","volume":"30","author":"Dorey C.K.","year":"1989","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.3109\/10409238.2012.694844"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2717"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.812774"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08938"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2009.139"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.189"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.262758.115"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.2147\/cia.s2777"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10735\u2010013\u20109483\u2010x"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00100"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12286"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759091414562107"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891\u20105849(91)90192\u20106"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.4.6.1023"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox7100130"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2015.09.020"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2005.05.012"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12551\u2010022\u201000989\u20109"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2018.09.011"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2013.168"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.131.6.1435"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1859"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2010.05.007"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2015.09.002"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00073.2016"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900173"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010019\u20100675\u20100"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201796697"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01875"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102377\u201013\u2010110"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2016.11.016"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301974"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M108995200"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02263"},{"issue":"7","key":"e_1_2_9_106_1","first-page":"1500","article-title":"Efficacy of intravitreal pegcetacoplan in patients with geographic atrophy (GA): 12\u2010month results from the phase 3 OAKS and DERBY studies","volume":"63","author":"Goldberg R.","year":"2022","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010019\u20100215\u20107"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2018.01.009"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1201940"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0737556100"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1673\u20105374.2013.21.009"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00005.2018"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.612812"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2018.03.010"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0501536102"},{"key":"e_1_2_9_116_1","volume-title":"Webvision: the organization of the retina and visual system","author":"Hageman G.S.","year":"2008"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1350\u20109462(01)00010\u20106"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2010.01.002"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12467"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1636"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010015\u20102087\u20108"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2013.03.048"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2012.03.006"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0000000000000427"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10317"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2005.06.028"},{"issue":"9","key":"e_1_2_9_127_1","first-page":"3091","article-title":"Activation and role of MAP kinase\u2010dependent pathways in retinal pigment epithelial cells: ERK and RPE cell proliferation","volume":"43","author":"Hecquet C.","year":"2002","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11213453"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501388"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3801"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102044.2011.07011.x"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004170050209"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.11.041"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07725"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1631"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04\u20100404"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1419"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.08.003"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.6943"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2013.02.008"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0801537"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2007.05.015"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1051\/medsci\/20132911013"},{"key":"e_1_2_9_144_1","volume-title":"The complement system and innate immunity, Immunobiology: the immune system in health and disease","author":"Janeway C.A.","year":"2001"},{"issue":"7","key":"e_1_2_9_145_1","doi-asserted-by":"crossref","first-page":"3957","DOI":"10.4049\/jimmunol.163.7.3957","article-title":"Regulation of complement activation by C\u2010reactive protein: targeting the complement inhibitory activity of factor H by an interaction with short consensus repeat domains 7 and 8\u201011","volume":"163","author":"Jarva H.","year":"1999","journal-title":"Journal of Immunology"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.06.014"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072354"},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2013.12.008"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2022.2069437"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2018.07.010"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20102374"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109\u2010008\u20100418\u2010z"},{"key":"e_1_2_9_153_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.24546"},{"key":"e_1_2_9_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2020.100858"},{"key":"e_1_2_9_155_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.28899"},{"key":"e_1_2_9_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.03.002"},{"key":"e_1_2_9_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2012.05.005"},{"key":"e_1_2_9_158_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010016\u20102147\u20108"},{"key":"e_1_2_9_159_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010018\u20100001\u20106"},{"key":"e_1_2_9_160_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401850"},{"key":"e_1_2_9_161_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxp017"},{"key":"e_1_2_9_162_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1863"},{"key":"e_1_2_9_163_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a016394"},{"key":"e_1_2_9_164_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00461"},{"key":"e_1_2_9_165_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201540352"},{"key":"e_1_2_9_166_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13127"},{"key":"e_1_2_9_167_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20133328"},{"key":"e_1_2_9_168_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00010"},{"key":"e_1_2_9_169_1","doi-asserted-by":"publisher","DOI":"10.2147\/opth.s367089"},{"key":"e_1_2_9_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(23)01583\u20100"},{"key":"e_1_2_9_171_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e04\u201006\u20100477"},{"key":"e_1_2_9_172_1","doi-asserted-by":"publisher","DOI":"10.5607\/en.2015.24.4.325"},{"key":"e_1_2_9_173_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.TR120000742"},{"key":"e_1_2_9_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2007.03.034"},{"key":"e_1_2_9_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1074\u20105521(01)00056\u20104"},{"key":"e_1_2_9_176_1","doi-asserted-by":"publisher","DOI":"10.1097\/IIO.0000000000000073"},{"key":"e_1_2_9_177_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2008\u20100345OC"},{"key":"e_1_2_9_178_1","doi-asserted-by":"publisher","DOI":"10.2741\/2853"},{"key":"e_1_2_9_179_1","volume-title":"Age\u2010related macular degeneration \u2013 etiology, diagnosis and management \u2013 a glance at the future","author":"Kolar P.","year":"2013"},{"key":"e_1_2_9_180_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2021"},{"key":"e_1_2_9_181_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2017.1384887"},{"key":"e_1_2_9_182_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201902355RR"},{"key":"e_1_2_9_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.07.008"},{"key":"e_1_2_9_184_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102012\u201002\u2010412080"},{"key":"e_1_2_9_185_1","doi-asserted-by":"publisher","DOI":"10.3109\/08830185.2010.529976"},{"key":"e_1_2_9_186_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12071379"},{"key":"e_1_2_9_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978\u20100\u2010323\u201035775\u20103.00021\u20107"},{"key":"e_1_2_9_188_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0702504104"},{"key":"e_1_2_9_189_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2020.100846"},{"key":"e_1_2_9_190_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.05.013"},{"key":"e_1_2_9_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0962\u20108924(98)01346\u20104"},{"key":"e_1_2_9_192_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.266"},{"key":"e_1_2_9_193_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.18.1.30"},{"key":"e_1_2_9_194_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.07.005"},{"key":"e_1_2_9_195_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096\u20109896(200002)190:3<343::AID\u2010PATH522>3.0.CO;2\u2010M"},{"key":"e_1_2_9_196_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.788634"},{"key":"e_1_2_9_197_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.834289"},{"issue":"1","key":"e_1_2_9_198_1","first-page":"1","article-title":"Relationship between the proteasomal system and autophagy","volume":"4","author":"Lilienbaum A.","year":"2013","journal-title":"International Journal of Biochemistry and Molecular Biology"},{"key":"e_1_2_9_199_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature00904"},{"key":"e_1_2_9_200_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1320294111"},{"key":"e_1_2_9_201_1","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2017.0073"},{"key":"e_1_2_9_202_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2009.06.005"},{"key":"e_1_2_9_203_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418\u2010017\u20100017\u2010z"},{"key":"e_1_2_9_204_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440\u20101681.2002.03649.x"},{"issue":"6","key":"e_1_2_9_205_1","first-page":"922","article-title":"Toll\u2010like receptor 3 and interleukin 1\u03b2 expression in CD34+ cells from patients with rheumatoid arthritis: association with inflammation and vascular involvement","volume":"32","author":"Lo Gullo A.","year":"2014","journal-title":"Clinical and Experimental Rheumatology"},{"key":"e_1_2_9_206_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00450"},{"key":"e_1_2_9_207_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2013.01.003"},{"key":"e_1_2_9_208_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.422238"},{"key":"e_1_2_9_209_1","doi-asserted-by":"publisher","DOI":"10.1590\/0004\u2010282X20190151"},{"key":"e_1_2_9_210_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02607"},{"key":"e_1_2_9_211_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12618"},{"key":"e_1_2_9_212_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00467"},{"key":"e_1_2_9_213_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00367.2004"},{"key":"e_1_2_9_214_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2009.01.008"},{"key":"e_1_2_9_215_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.8.1.18174"},{"key":"e_1_2_9_216_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010022\u201000760\u2010x"},{"key":"e_1_2_9_217_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04515"},{"key":"e_1_2_9_218_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2005.08.004"},{"key":"e_1_2_9_219_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16278"},{"key":"e_1_2_9_220_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04516"},{"key":"e_1_2_9_221_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2013.12.006"},{"key":"e_1_2_9_222_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2525"},{"key":"e_1_2_9_223_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200910140"},{"key":"e_1_2_9_224_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673\u20105374.369098"},{"key":"e_1_2_9_225_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00328.2013"},{"key":"e_1_2_9_226_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000002499"},{"key":"e_1_2_9_227_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M300931200"},{"key":"e_1_2_9_228_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00262"},{"key":"e_1_2_9_229_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00257"},{"key":"e_1_2_9_230_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2017.04.005"},{"key":"e_1_2_9_231_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04946"},{"key":"e_1_2_9_232_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114515002093"},{"key":"e_1_2_9_233_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9030740"},{"key":"e_1_2_9_234_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2014.6126"},{"key":"e_1_2_9_235_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2013.10.009"},{"issue":"2","key":"e_1_2_9_236_1","doi-asserted-by":"crossref","first-page":"882","DOI":"10.4049\/jimmunol.133.2.882","article-title":"C\u2010reactive protein inhibits pneumococcal activation of the alternative pathway by increasing the interaction between factor H and C3b","volume":"133","author":"Mold C.","year":"1984","journal-title":"Journal of Immunology"},{"key":"e_1_2_9_237_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030874"},{"key":"e_1_2_9_238_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.05.016"},{"key":"e_1_2_9_239_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1117765109"},{"key":"e_1_2_9_240_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.1070280107"},{"key":"e_1_2_9_241_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20110367"},{"key":"e_1_2_9_242_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1980"},{"key":"e_1_2_9_243_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.6.8.13426"},{"key":"e_1_2_9_244_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200809125"},{"issue":"4","key":"e_1_2_9_245_1","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.4049\/jimmunol.157.4.1693","article-title":"C3a and C5a are chemotaxins for human mast cells and act through distinct receptors via a pertussis toxin\u2010sensitive signal transduction pathway","volume":"157","author":"Nilsson G.","year":"1996","journal-title":"Journal of Immunology"},{"key":"e_1_2_9_246_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523\u20101755.2004.00465.x"},{"issue":"1","key":"e_1_2_9_247_1","first-page":"140","article-title":"Thrombin generates monocyte chemotactic activity from complement factor H","volume":"80","author":"Ohtsuka H.","year":"1993","journal-title":"Immunology"},{"key":"e_1_2_9_248_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2015.07.003"},{"key":"e_1_2_9_249_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2016.1208889"},{"key":"e_1_2_9_250_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20080083"},{"key":"e_1_2_9_251_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.583943"},{"key":"e_1_2_9_252_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2013.05.001"},{"key":"e_1_2_9_253_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010016\u20102418\u20104"},{"key":"e_1_2_9_254_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.05.008"},{"key":"e_1_2_9_255_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/435607"},{"key":"e_1_2_9_256_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2011.06.009"},{"key":"e_1_2_9_257_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5371"},{"key":"e_1_2_9_258_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2012.11.005"},{"key":"e_1_2_9_259_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882\u2010018\u20100817\u20103"},{"key":"e_1_2_9_260_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101114"},{"key":"e_1_2_9_261_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19010325"},{"key":"e_1_2_9_262_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2012.06.003"},{"key":"e_1_2_9_263_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10030537"},{"key":"e_1_2_9_264_1","doi-asserted-by":"publisher","DOI":"10.1159\/000492886"},{"key":"e_1_2_9_265_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201025123\u20102"},{"key":"e_1_2_9_266_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2014.09.015"},{"key":"e_1_2_9_267_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8416763"},{"key":"e_1_2_9_268_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00258"},{"key":"e_1_2_9_269_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2000398"},{"key":"e_1_2_9_270_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102249.2002.01965.x"},{"key":"e_1_2_9_271_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.426254"},{"key":"e_1_2_9_272_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094875"},{"key":"e_1_2_9_273_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21134627"},{"key":"e_1_2_9_274_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12206"},{"key":"e_1_2_9_275_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2007"},{"key":"e_1_2_9_276_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2014.6062"},{"key":"e_1_2_9_277_1","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.96601"},{"key":"e_1_2_9_278_1","doi-asserted-by":"publisher","DOI":"10.4103\/jovr.jovr_182_17"},{"key":"e_1_2_9_279_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.112.21.3667"},{"key":"e_1_2_9_280_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms160819458"},{"key":"e_1_2_9_281_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742\u20104682\u20107\u201025"},{"key":"e_1_2_9_282_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2018.08.036"},{"key":"e_1_2_9_283_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.32.18825"},{"key":"e_1_2_9_284_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22031296"},{"key":"e_1_2_9_285_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2010.12.003"},{"key":"e_1_2_9_286_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00327"},{"key":"e_1_2_9_287_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010020\u201002024\u20108"},{"key":"e_1_2_9_288_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2008.10.004"},{"key":"e_1_2_9_289_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.16.1793"},{"key":"e_1_2_9_290_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.6.704"},{"key":"e_1_2_9_291_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1059"},{"key":"e_1_2_9_292_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2012.72"},{"key":"e_1_2_9_293_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201848070"},{"key":"e_1_2_9_294_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00857\u201013"},{"key":"e_1_2_9_295_1","doi-asserted-by":"publisher","DOI":"10.3934\/molsci.2016.2.196"},{"key":"e_1_2_9_296_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2215"},{"key":"e_1_2_9_297_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.01.009"},{"key":"e_1_2_9_298_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010022\u201000456\u2010z"},{"key":"e_1_2_9_299_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01649"},{"key":"e_1_2_9_300_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2119"},{"key":"e_1_2_9_301_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.10.445"},{"key":"e_1_2_9_302_1","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.13834"},{"key":"e_1_2_9_303_1","doi-asserted-by":"publisher","DOI":"10.1177\/0192623311428478"},{"key":"e_1_2_9_304_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13067"},{"issue":"6","key":"e_1_2_9_305_1","first-page":"1356","article-title":"Blue light\u2010induced apoptosis of A2E\u2010containing RPE: involvement of caspase\u20103 and protection by Bcl\u20102","volume":"42","author":"Sparrow J.R.","year":"2001","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_9_306_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0042\u20106989(03)00475\u20109"},{"key":"e_1_2_9_307_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2012.03.007"},{"issue":"4","key":"e_1_2_9_308_1","first-page":"1222","article-title":"Involvement of oxidative mechanisms in blue\u2010light\u2010induced damage to A2E\u2010laden RPE","volume":"43","author":"Sparrow J.R.","year":"2002","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_9_309_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2009.04.029"},{"key":"e_1_2_9_310_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00754"},{"key":"e_1_2_9_311_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00021.2004"},{"key":"e_1_2_9_312_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00158"},{"key":"e_1_2_9_313_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5080843"},{"key":"e_1_2_9_314_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2020.103949"},{"key":"e_1_2_9_315_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10111559"},{"key":"e_1_2_9_316_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.48064"},{"key":"e_1_2_9_317_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M007049200"},{"key":"e_1_2_9_318_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12458"},{"key":"e_1_2_9_319_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.113.300867"},{"key":"e_1_2_9_320_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1121572109"},{"key":"e_1_2_9_321_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.036"},{"key":"e_1_2_9_322_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0391509"},{"key":"e_1_2_9_323_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10522\u2010019\u201009808\u20103"},{"key":"e_1_2_9_324_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201003509\u20100"},{"key":"e_1_2_9_325_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1457"},{"key":"e_1_2_9_326_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.02.005"},{"key":"e_1_2_9_327_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00742\u201012"},{"key":"e_1_2_9_328_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12\u201010655"},{"key":"e_1_2_9_329_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2993"},{"key":"e_1_2_9_330_1","doi-asserted-by":"publisher","DOI":"10.2174\/157015909787602823"},{"key":"e_1_2_9_331_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34508"},{"key":"e_1_2_9_332_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.7.12.17893"},{"key":"e_1_2_9_333_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6659"},{"key":"e_1_2_9_334_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13175"},{"key":"e_1_2_9_335_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.4.1309"},{"key":"e_1_2_9_336_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M800706200"},{"key":"e_1_2_9_337_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.29583"},{"key":"e_1_2_9_338_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460\u20102075.1995.tb07149.x"},{"key":"e_1_2_9_339_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010genet\u2010102108\u2010134850"},{"key":"e_1_2_9_340_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2018.9089"},{"key":"e_1_2_9_341_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2017.09.009"},{"key":"e_1_2_9_342_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043896"},{"key":"e_1_2_9_343_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2013.06.009"},{"key":"e_1_2_9_344_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2096"},{"key":"e_1_2_9_345_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.21"},{"key":"e_1_2_9_346_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2012.02.033"},{"key":"e_1_2_9_347_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0741\u20105214(99)70329\u20100"},{"key":"e_1_2_9_348_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2006.12.002"},{"key":"e_1_2_9_349_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12920\u2010020\u201000760\u20107"},{"key":"e_1_2_9_350_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378\u20104274(95)03532\u2010x"},{"key":"e_1_2_9_351_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214\u2010109X(13)70145\u20101"},{"key":"e_1_2_9_352_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S206355"},{"key":"e_1_2_9_353_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092\u20108674(00)80611\u2010X"},{"key":"e_1_2_9_354_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2020.02.006"},{"key":"e_1_2_9_355_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2009.06.001"},{"key":"e_1_2_9_356_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.609441"},{"key":"e_1_2_9_357_1","doi-asserted-by":"publisher","DOI":"10.1247\/csf.23.33"},{"key":"e_1_2_9_358_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M806084200"},{"key":"e_1_2_9_359_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.727870"},{"key":"e_1_2_9_360_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0139416"},{"key":"e_1_2_9_361_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026\u2010012\u20108317\u20103"},{"key":"e_1_2_9_362_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2017.241"},{"key":"e_1_2_9_363_1","doi-asserted-by":"publisher","DOI":"10.1016\/0039\u20106257(87)90115\u20109"},{"key":"e_1_2_9_364_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.122.4.598"},{"key":"e_1_2_9_365_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.05.036"},{"key":"e_1_2_9_366_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102006\u201012\u2010063636"},{"key":"e_1_2_9_367_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010030\u201066014\u20107_5"},{"key":"e_1_2_9_368_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2896036"},{"key":"e_1_2_9_369_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2020.06.016"},{"key":"e_1_2_9_370_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2019.4188"},{"key":"e_1_2_9_371_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41421\u2010020\u20100167\u2010x"},{"key":"e_1_2_9_372_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.667454"},{"key":"e_1_2_9_373_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2014.163"},{"key":"e_1_2_9_374_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00333"},{"key":"e_1_2_9_375_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000234904.43861.f7"},{"key":"e_1_2_9_376_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.12.057"},{"key":"e_1_2_9_377_1","first-page":"116","article-title":"TRPM2 links oxidative stress to the NLRP3 inflammasome activation (P1268)","volume":"190","author":"Zhong Z.","year":"2013","journal-title":"Journal of Immunology"},{"key":"e_1_2_9_378_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0604255103"},{"key":"e_1_2_9_379_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1831"},{"key":"e_1_2_9_380_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09663"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.16661","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T00:11:07Z","timestamp":1710202267000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.16661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":379,"journal-issue":{"issue":"S282","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/aos.16661"],"URL":"https:\/\/doi.org\/10.1111\/aos.16661","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"2024-01-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}