{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:50:54Z","timestamp":1772999454238,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","award":["IIT\u20102018\u201010559"],"award-info":[{"award-number":["IIT\u20102018\u201010559"]}],"id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the surgical success and efficacy of XEN45 implantation (XEN45\u2009\u03bcm, AbbVie Inc., USA) with and without combined cataract surgery up to the first 5\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In a prospective observational monocentric trial, 192 eyes of 157 patients with open\u2010angle glaucoma received either XEN45 implants only (\n                      <jats:italic>solo surgery group<\/jats:italic>\n                      ) or combined surgery\/cataract surgeries (\n                      <jats:italic>combined surgery group<\/jats:italic>\n                      ). Surgical success (qualified and full success; IOP\u2010limit: \u226412, 15, 18, 21\u2009mmHg), time to secondary IOP\u2010lowering procedure, IOP and number of IOP\u2010lowering medications were analysed for 1, 2, 3, 4 and 5\u2009years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to baseline, IOP (24.1\u2009\u00b1\u20098.1 to 12.6\u2009\u00b1\u20092.8\u2009mmHg, \u221248%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and the number of IOP\u2010lowering medications (3.0\u2009\u00b1\u20091.0 to 1.5\u2009\u00b1\u20091.2, \u221250%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) decreased significantly at 5\u2009years. Although no differences between IOP and the number of IOP\u2010lowering medication courses between the groups were detected at 5\u2009years (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.11), the combined procedure (63%, 37%) showed better success rates compared to the solo procedure (36%, 13%) in the definition IOP \u226418 and \u226412\u2009mmHg (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.035, 0.028). Solo XEN45 procedures had a higher rate of secondary IOP\u2010lowering procedures compared to combined XEN45 cataract procedures (hazard ratio: 2.02, 95%CI: 1.03\u20133.97,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04). Twenty per cent of the eyes, including both procedures, required a secondary IOP\u2010lowering procedure within 5\u2009years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The XEN45 implant is effective in lowering IOP and the number of IOP\u2010lowering medications in patients with open\u2010angle glaucoma in the mid\u2010term. Comparing XEN45 implant results with the results of trabeculectomy available in current literature, we speculate that there might be a higher surgical success rate without medications in favour of trabeculectomy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.16668","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T10:36:15Z","timestamp":1710326175000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Mid\u2010term surgical success after transscleral ab interno glaucoma gel stent implantation"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5299-7330","authenticated-orcid":false,"given":"Markus","family":"Lenzhofer","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Optometry Paracelsus Medical University Salzburg, Salzburger Landeskliniken  Salzburg Austria"},{"name":"Research Program Experimental 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Salzburger Landeskliniken  Salzburg Austria"},{"name":"Research and Innovation Management (RIM), Team Biostatistics and Publication of Clinical Trial Studies\/Machine Learning Paracelsus Medical University Salzburg  Salzburg Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Runge","sequence":"additional","affiliation":[{"name":"Research Program Experimental Ophthalmology Paracelsus Medical University Salzburg, Salzburger Landeskliniken  Salzburg Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Trost","sequence":"additional","affiliation":[{"name":"Research Program Experimental Ophthalmology Paracelsus Medical University Salzburg, Salzburger Landeskliniken  Salzburg Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans Peter","family":"Colvin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Optometry Paracelsus Medical University Salzburg, 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