{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:50:58Z","timestamp":1772999458708,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:00:00Z","timestamp":1711497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:00:00Z","timestamp":1711497600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Peripheral hypertrophic subepithelial corneal opacification (PHSCO) is a corneal disease that may severely affect vision. The major goal of this study was to test the hypothesis that tear secretion, medication and systemic diseases are associated with PHSCO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a retrospective, case\u2013control study conducted at the Department of Ophthalmology, University Medical Center of the Johannes Gutenberg University Mainz. We analysed medical records of patients diagnosed with PHSCO. Sex, age, Schirmer's test II, general medication and medical history were assessed and compared to an age\u2010 and sex\u2010matched control group from the Gutenberg Health Study (GHS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One hundred ninety\u2010five eyes of 112 patients with PHSCO were included. Eighty\u2010eight patients were female with a mean age of 55.3\u2009\u00b1\u200914.7\u2009years (23\u201389\u2009years) and 24 patients were male with a mean age of 59.3\u2009\u00b1\u200912.6\u2009years (38\u201384\u2009years). In 83 patients (74.1%) both eyes were involved. The Schirmer's test II was significantly reduced in patients with PHSCO compared to the GHS control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Patients with PHSCO were more frequently administered artificial tears and steroid eye drops (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and were more hyperopic than healthy controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01). Systemic diseases or medication did not differ markedly between PHSCO and healthy controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Reduced tear secretion and more frequent use of artificial tears in patients with PHSCO suggest a link between PHSCO and dry eye disease. The results of the study do not support our hypothesis that PHSCO is associated with systemic diseases. Interestingly, patients with PHSCO were less frequently on \u03b2\u2010blockers than control subjects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.16680","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T12:39:09Z","timestamp":1711543149000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Peripheral hypertrophic subepithelial corneal opacification \u2013 Role of tear secretion, medication and systemic diseases"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8015-846X","authenticated-orcid":false,"given":"Jana C.","family":"Riedl","sequence":"first","affiliation":[{"name":"Department of Ophthalmology University Medical Center, Johannes Gutenberg\u2010University Mainz  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aminat","family":"Misirkhanova","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Medical Center, Johannes Gutenberg\u2010University Mainz  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7025-8280","authenticated-orcid":false,"given":"Joanna","family":"Wasielica\u2010Poslednik","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Medical Center, Johannes Gutenberg\u2010University Mainz  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander\u00a0K.","family":"Schuster","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Medical Center, Johannes Gutenberg\u2010University Mainz  Mainz 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