{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T02:05:52Z","timestamp":1793066752490,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To study the risk for eye diseases in individuals with Ulcerative Colitis (UC), and to assess whether silica dust\u2010exposure could contribute to the development of inflammatory eye diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A case\u2013control study was conducted using a patient register processed by the National Board of Health and Welfare (NBHW) and <jats:italic>Statistics Sweden<\/jats:italic>. Cases were diagnosed with UC between 2007 and 2016. Matching was done with two random controls having the same age, sex and county of residence, without a systemic inflammatory disease. Using a job\u2010exposure matrix, cases and controls were assessed for work\u2010related silica dust exposure. The risk for eye disease was estimated by Cox regression analysis with calculation of Hazard Ratio (HR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 58\u2009989 individuals were included, comprising 19\u2009663 cases and 39\u2009326 controls. The sex distribution was similar. Overall, individuals with UC had an increased risk for eye disease, specified in ICD 10 chapter VII (H00\u2010H59) with HR 1.25 (CI 1.20\u20131.32). The highest HR on block\u2010level for cases was 1.52 (CI 1.36\u20131.70), (H15\u2010H22), which includes episcleritis, keratitis and anterior uveitis. The risk for ocular disease was higher in silica dust\u2010exposed than non\u2010exposed with a HR of 1.44 (CI 1.16\u20131.78) and 1.25 (CI 1.19\u20131.31), respectively. Among cases, the risk for iridocyclitis (H20) was further elevated by silica dust exposure, with HR of 3.84 (CI 1.64\u20138.97) in exposed compared to 1.94 (1.57\u20132.41) in non\u2010exposed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>UC is associated with an increased risk for eye diseases, including inflammatory conditions. Our findings highlight that silica dust\u2010exposure may be of importance in the pathogenesis of uveitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.16708","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T09:19:19Z","timestamp":1715591959000},"page":"828-835","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The risk for ophthalmological conditions in ulcerative colitis: A population\u2010based case\u2013control study. 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