{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T19:45:54Z","timestamp":1775677554068,"version":"3.50.1"},"reference-count":51,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T00:00:00Z","timestamp":1716940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013500","name":"Diabetestutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013500","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005633","name":"Syd\u00e4ntutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004325","name":"Signe ja Ane Gyllenbergin S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013510","name":"Silm\u00e4- ja kudospankkis\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013510","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006306","name":"Sigrid Jus\u00e9liuksen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008273","name":"\u00d8jenfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008273","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010114","name":"Yrj\u00f6 Jahnssonin S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010114","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015738","name":"Mary och Georg C. Ehrnrooths Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011905","name":"Evald ja Hilda Nissin S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011905","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["33405"],"award-info":[{"award-number":["33405"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008723","name":"Suomen L\u00e4\u00e4ketieteen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004037","name":"Juho Vainion S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004037","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To explore foveal and parafoveal thickness in adults born preterm with very low birth weight (VLBW) and its association with best\u2010corrected visual acuity (BCVA) and gestational age (GA) compared to adults born at term.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a joint study of the Helsinki Study of Very Low Birth Weight Adults (Finland) and the NTNU Low Birth Weight Life study (Norway), 106 VLBW and 143 term\u2010born controls were examined with spectral\u2010domain optical coherence tomography and BCVA at age 31\u201343\u2009years. Thickness of retinal layers was segmented in the foveal and parafoveal areas of the macula.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The total retinal thickness in the foveal area was thicker in VLBW adults compared with controls; mean (SD): 292.5\u2009\u03bcm (28.2) and 272.4\u2009\u03bcm (20.2); <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, and thinner in the parafoveal areas of the macula. These findings could be explained by a thicker inner retinal layer in the foveal area found in VLBW adults compared with controls (mean difference 20.4\u2009\u03bcm; CI: 15.0 to 25.9), where a thicker fovea was associated with lower GA, but not BCVA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adults born preterm with VLBW had a thicker retina in the foveal area than controls and this was associated with GA, but not with BCVA. These changes seem to be related to a thicker inner retinal layer in VLBW adults. The findings imply that signs of macular underdevelopment are still present in adulthood, but not necessarily related to reduced visual function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.16725","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T12:53:42Z","timestamp":1716987222000},"page":"942-952","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Foveal thickness and its association with visual acuity in adults born preterm with very low birth weight: A two\u2010country birth cohort study"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5069-901X","authenticated-orcid":false,"given":"Anna P. M.","family":"J\u00f8rgensen","sequence":"first","affiliation":[{"name":"Department of Neuromedicine and Movement Science Norwegian University of Science and Technology (NTNU)  Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maarit","family":"Kulmala","sequence":"additional","affiliation":[{"name":"Public Health Unit Finnish Institute for Health and Welfare  Helsinki\/Oulu Finland"},{"name":"Department of Ophthalmology Helsinki University Hospital  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9782-576X","authenticated-orcid":false,"given":"Dordi","family":"Austeng","sequence":"additional","affiliation":[{"name":"Department of Neuromedicine and Movement Science Norwegian University of Science and Technology (NTNU)  Trondheim Norway"},{"name":"Department of Ophthalmology, St. Olavs Hospital Trondheim University Hospital  Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kari Anne I.","family":"Evensen","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine NTNU  Trondheim Norway"},{"name":"Children's Clinic, St. Olavs Hospital Trondheim University Hospital  Trondheim Norway"},{"name":"Department of Rehabilitation Science and Health Technology Oslo Metropolitan University  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eero","family":"Kajantie","sequence":"additional","affiliation":[{"name":"Public Health Unit Finnish Institute for Health and Welfare  Helsinki\/Oulu Finland"},{"name":"Department of Clinical and Molecular Medicine NTNU  Trondheim Norway"},{"name":"Clinical Medicine Research Unit, Oulu University Hospital University of Oulu  Oulu Finland"},{"name":"Children's Hospital Helsinki University Hospital  Helsinki Finland"},{"name":"University of Helsinki  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7145-063X","authenticated-orcid":false,"given":"Anna","family":"Majander","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Helsinki University Hospital  Helsinki Finland"},{"name":"University of Helsinki  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5876-284X","authenticated-orcid":false,"given":"Tora Sund","family":"Morken","sequence":"additional","affiliation":[{"name":"Department of Neuromedicine and Movement Science Norwegian University of Science and Technology (NTNU)  Trondheim Norway"},{"name":"Department of Ophthalmology, St. Olavs Hospital Trondheim University Hospital  Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2010.184747"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12886\u2010022\u201002488\u20107"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517\u20106161.1995.tb02031.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2013.205"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/children10101683"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15\u201018843"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062655"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2019.09.013"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417\u2010018\u20104162\u2010y"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11051337"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol\u20102017\u2010311345"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010vision\u2010082114\u2010035334"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12890"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417\u2010017\u20103662\u20105"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2016.0391"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2007.08.012"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067187"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05\u20101396"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201014616\u20102"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04\u20100335"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390\u2010023\u201002896\u20105"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12694"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.08.037"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2019.09.018"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.15683"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.6.825"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15\u201016542"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100420.2006.00808.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100420.2007.01133.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417\u2010020\u201004986\u20100"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2023.1238193"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12695"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/iae.0000000000001469"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.13418"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15\u201018583"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100420.2001.790609.x"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.62.2.25"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol\u20102019\u2010314429"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2023.108277"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2014.12.015"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13085"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/opo.12221"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/iae.0000000000002581"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2465"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606\u2010013\u20102755\u2010z"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433\u2010019\u20100627\u20104"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10\u20106365"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433\u2010022\u201002237\u20106"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2014.05.017"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.05.021"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol\u20102012\u2010301612"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.16725","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T01:30:56Z","timestamp":1731375056000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.16725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,29]]},"references-count":51,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1111\/aos.16725"],"URL":"https:\/\/doi.org\/10.1111\/aos.16725","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,29]]},"assertion":[{"value":"2024-01-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}