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Well\u2010functioning meibomian glands are paramount for maintaining a stable tear film, and their dysfunction is the most common cause of dry eye disease. There is a growing concern that both topical glaucoma medications themselves and their added preservatives damage the meibomian glands, and consequently, the ocular surface. Preserved topical glaucoma medications appear to cause dysfunction and atrophy of the meibomian glands. Upon comparison, preserved formulations caused more symptoms of dry eye, tear film instability, inflammatory changes and meibomian gland dropout than the preservative\u2010free counterpart. However, although seemingly less detrimental, unpreserved alternatives may diminish glandular efficacy, and, depending on the active ingredient, lead to glandular death. This negatively impacts quality of life, adherence to treatment regimens and prognosis. In this review, we explore the available evidence regarding the effects of IOP\u2010lowering eye drops on the meibomian glands.<\/jats:p>","DOI":"10.1111\/aos.16728","type":"journal-article","created":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T09:18:40Z","timestamp":1717233520000},"page":"735-748","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Topical glaucoma medications \u2212 Possible implications on the meibomian glands"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3835-8772","authenticated-orcid":false,"given":"Fredrik","family":"Fineide","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry Oslo University Hospital  Oslo Norway"},{"name":"The Norwegian Dry Eye Clinic  Oslo Norway"},{"name":"Department of Computer Science Oslo Metropolitan University  Oslo Norway"},{"name":"SimulaMet  Oslo 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