{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T15:53:14Z","timestamp":1756309994649,"version":"3.32.0"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,6,23]],"date-time":"2024-06-23T00:00:00Z","timestamp":1719100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To develop and evaluate a photovoltaic, wireless wide\u2010field epiretinal prosthesis for the treatment of retinitis pigmentosa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A mosaic array of thinned silicon\u2010based photodiodes with integrated thin\u2010film stimulation electrodes was fabricated with a flexible polyimide substrate film to form a film\u2010based miniaturized electronic system with wireless optical power and signal transmission and integrated electrostimulation. Manufactured implants were characterized with respect to their optoelectronic performance and biocompatibility following DIN EN ISO 10993.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A 14\u2009mm diameter prosthesis containing 1276 pixels with a maximum sensitivity at a near infrared wavelength of 905\u2009nm and maximized stimulation current density 30\u201350\u2009\u03bcm below the electrodes was developed for direct activation of retinal ganglion cells during epiretinal stimulation. Fabricated prostheses demonstrated mucosal tolerance and the preservation of both metabolic activity, proliferation and membrane integrity of human fibroblasts as well as the retinal functions of bovine retinas. Illumination of the prosthesis, which was placed epiretinally on an isolated perfused bovine retina, with infrared light resulted in electrophysiological recordings reminiscent of an a\u2010wave (hyperpolarization) and b\u2010wave (depolarization).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A photovoltaic, wireless wide\u2010field epiretinal prosthesis for the treatment of retinitis pigmentosa using near infrared light for signal transmission was designed, manufactured and its biocompatibility and functionality demonstrated in\u00a0vitro and ex\u00a0vivo.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.16733","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T03:38:48Z","timestamp":1719200328000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Photovoltaic, wireless wide\u2010field epiretinal prosthesis to treat retinitis pigmentosa"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2445-9118","authenticated-orcid":false,"given":"Andr\u00e9","family":"Schulz","sequence":"first","affiliation":[{"name":"Eye Clinic Sulzbach, Knappschaft Hospital Saar  Sulzbach Germany"},{"name":"Klaus Heimann Eye Research Institute  Sulzbach Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thorsten","family":"Knoll","sequence":"additional","affiliation":[{"name":"Fraunhofer Institute for Biomedical Engineering IBMT  Sulzbach Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tino","family":"Jaeger","sequence":"additional","affiliation":[{"name":"PREMA Semiconductor GmbH  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronan","family":"Le Harzic","sequence":"additional","affiliation":[{"name":"Fraunhofer Institute for Biomedical Engineering IBMT  Sulzbach Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Stracke","sequence":"additional","affiliation":[{"name":"Fraunhofer Institute for Biomedical Engineering IBMT  Sulzbach Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sascha L.","family":"Wien","sequence":"additional","affiliation":[{"name":"Fraunhofer Institute for Biomedical Engineering IBMT  Sulzbach Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Olsommer","sequence":"additional","affiliation":[{"name":"Fraunhofer Institute for Biomedical Engineering IBMT  Sulzbach Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ina","family":"Meiser","sequence":"additional","affiliation":[{"name":"Fraunhofer Institute for Biomedical Engineering IBMT  Sulzbach Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvia","family":"Wagner","sequence":"additional","affiliation":[{"name":"Fraunhofer Institute for Biomedical Engineering IBMT  Sulzbach Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Rammensee","sequence":"additional","affiliation":[{"name":"PREMA Semiconductor GmbH  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Kurz","sequence":"additional","affiliation":[{"name":"PREMA Semiconductor GmbH  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Klesy","sequence":"additional","affiliation":[{"name":"PREMA Semiconductor GmbH  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loic","family":"Sermeus","sequence":"additional","affiliation":[{"name":"Eye Clinic Sulzbach, Knappschaft Hospital Saar  Sulzbach Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrike","family":"Julich\u2010Haertel","sequence":"additional","affiliation":[{"name":"Eye Clinic Sulzbach, Knappschaft Hospital Saar  Sulzbach Germany"},{"name":"Klaus Heimann Eye Research Institute  Sulzbach Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanick","family":"Schweitzer","sequence":"additional","affiliation":[{"name":"Eye Clinic Sulzbach, Knappschaft Hospital Saar  Sulzbach Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Januschowski","sequence":"additional","affiliation":[{"name":"Eye Clinic Sulzbach, Knappschaft Hospital Saar  Sulzbach Germany"},{"name":"Klaus Heimann Eye Research Institute  Sulzbach Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Velten","sequence":"additional","affiliation":[{"name":"Fraunhofer Institute for Biomedical Engineering IBMT  Sulzbach Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Szurman","sequence":"additional","affiliation":[{"name":"Eye Clinic Sulzbach, Knappschaft Hospital Saar  Sulzbach Germany"},{"name":"Klaus Heimann Eye Research Institute  Sulzbach Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2010.179622"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2560\/6\/3\/035002"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1109\/TNSRE.2011.2140132"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(92)90229-C"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43246-021-00133-2"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.12812"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2560\/4\/1\/S11"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/2013.jamaophthalmol.221"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2006.01.034"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.09.019"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0229189"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03386-7"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006324-199807000-00022"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2560\/10\/5\/056021"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1987.tb02804.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.10.10.8"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69740-7"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1BM01946E"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.04.032"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-49331-2_6"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.09.028"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.06.044"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2006.01.012"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-1018"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31599-4"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2552\/ab4113"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2008.04.005"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2015.09.003"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006324-198205000-00009"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nphoton.2012.104"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4968-08.2008"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2012.35"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2018.11.010"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2020.02.024"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28125-x"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2560\/2\/1\/012"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1997.01100150513011"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2015.03.001"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2552\/abb5bc"},{"key":"e_1_2_6_41_1","first-page":"773","volume-title":"Adler's physiology of the eye","author":"Tychsen L.","year":"1992"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31180-z"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1515\/cdbme-2020-2007"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1515\/cdbme-2019-0014"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-199911000-00012"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-925X-13-11"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-vision-111815-114425"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.08.008"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2016.05.002"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-017-1114-4"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.16733","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T09:12:57Z","timestamp":1736241177000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.16733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,23]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/aos.16733"],"URL":"https:\/\/doi.org\/10.1111\/aos.16733","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"type":"print","value":"1755-375X"},{"type":"electronic","value":"1755-3768"}],"subject":[],"published":{"date-parts":[[2024,6,23]]},"assertion":[{"value":"2023-05-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}