{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:12:51Z","timestamp":1790143971006,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To present baseline characteristics and to present the perioperative corneal thickness during corneal crosslinking (CXL) treatment for progressive keratoconus and to describe how the addition of sterile water (SW) efficaciously can maintain the corneal thickness. The treatment efficacy will be evaluated when the 1\u2010year follow\u2010up is complete.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A randomised clinical study using epithelium\u2010off CXL with continuous UVA irradiation (9\u2009mW\/cm\n                      <jats:sup>2<\/jats:sup>\n                      ) and two kinds of riboflavin solutions: (i) isoosmolar dextran\u2010based riboflavin (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200927) and (ii) hypoosmolar dextran\u2010free riboflavin (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200927). Inclusion criteria: progressive keratoconus with an increase in maximum keratometry value (Kmax) of 1.0 dioptre (12\u2009months) or 0.5 dioptres (6\u2009months). Corneae thinner than 400\u2009\u03bcm were also included. Outcome parameters: Perioperative corneal thickness and the effect of adding SW.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seventy\u2010four per cent of the patients in the isoosmolar group and 15% in the hypoosmolar group required the addition of SW, which effectively maintained a corneal thickness of 400\u2009\u03bcm in all cases during CXL. The addition of SW was primarily needed during the irradiation procedure and not the preoperative soaking period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Especially during the CXL irradiation phase, isoosmolar riboflavin causes a significant dehydrating effect leading to corneal thinning during CXL. The customised addition of SW is efficacious in maintaining the corneal thickness during CXL and could increase the safety of the procedure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.16736","type":"journal-article","created":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T01:00:03Z","timestamp":1720227603000},"page":"23-32","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Early findings in a randomised controlled trial on crosslinking protocols using isoosmolar and hypoosmolar riboflavin for the treatment of progressive keratoconus"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7001-0202","authenticated-orcid":false,"given":"Ingemar","family":"Gustafsson","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"},{"name":"Department of Clinical Sciences Lund University  Lund 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