{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T23:09:40Z","timestamp":1784761780065,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:00:00Z","timestamp":1720051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005431","name":"Pirkanmaan Rahasto","doi-asserted-by":"publisher","award":["50231610"],"award-info":[{"award-number":["50231610"]}],"id":[{"id":"10.13039\/501100005431","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate possible risk factors for uveitis among Finnish sarcoidosis patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patient charts of patients with sarcoidosis, with (<jats:italic>n<\/jats:italic>\u2009=\u200997) or without (<jats:italic>n<\/jats:italic>\u2009=\u2009255) uveitis, and with a comprehensive eye examination from January 2014 to January 2021 at Tays Eye Centre, Tampere University Hospital, Finland were studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sarcoidosis patients with uveitis had higher rate of lymphocytopenia (43% vs. 29%, <jats:italic>p<\/jats:italic>\u2009=\u20090.041) and lower serum lysozyme levels (2.0\u2009mg\/L vs. 2.3\u2009mg\/L, <jats:italic>p<\/jats:italic>\u2009=\u20090.049; 95% CI, \u22120.692 to \u22120.002). Lysozyme level or lymphocytopenia did not have a statistically significant effect on the probability of uveitis in a binary logistic regression analysis. No other differences in the potential risk factors with <jats:italic>p<\/jats:italic>\u2010values \u22640.05 were found, including bilateral hilar lymphadenopathy, serum angiotensin\u2010converting enzyme (ACE) levels, sex, age and history of smoking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Lymphocytopenia and lower serum lysozyme levels present as possible risk factors for uveitis among patients with sarcoidosis. Systematic measurement of lymphocyte and lysozyme levels in sarcoidosis is needed to further understand their role as potential risk factors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.16738","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T07:35:00Z","timestamp":1720078500000},"page":"16-22","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Risk factors for uveitis in a Finnish sarcoid population"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3442-2941","authenticated-orcid":false,"given":"Elli","family":"Joukainen","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health Technology Tampere University  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaakko","family":"Antonen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Tampere University Hospital  Tampere 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