{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T10:26:03Z","timestamp":1781864763735,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T00:00:00Z","timestamp":1723420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Treatment with glucocorticoids following paediatric cataract surgery is crucial to prevent inflammation, but may lead to secondary glaucoma, and hypothalamic\u2013pituitary\u2013adrenal axis suppression. We wish to compare glaucoma outcomes following high\u2010dose and low\u2010dose glucocorticoid treatment after paediatric cataract surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cohort study included Danish children undergoing cataract surgery before 10\u2009years of age, receiving either a low\u2010dose or high\u2010dose postoperative glucocorticoid treatment. Case identification and collection of a standardized dataset were retrospective, from 1 January 2010 to 31 December 2016, and prospective thereafter, until 31 December 2021. High\u2010dose treatment included 0.5\u20131.0\u2009mg subconjunctival depot dexamethasone or methylprednisolone, followed by 6\u20138 drops of dexamethasone for 1\u2009week, tapered by one drop weekly. Low\u2010dose treatment included 6 drops for 3\u2009days, followed by 3 drops for 18\u2009days. Sustained (&gt;3\u2009months) ocular hypertension or glaucoma was compared between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 267 children (388 eyes) were included in the study. Ninety\u2010five children (133 eyes) had received high\u2010dose treatment and had a median follow\u2010up time of 89\u2009months (IQR: 57.2\u2013107.4), while 173 children (255 eyes) had received the low\u2010dose treatment and had a median follow\u2010up time of 40.5\u2009months (IQR: 22.9\u201360.4). Survival curves showed a lower risk of glaucoma in the low\u2010dose group for children with axial lengths \u226518\u2009mm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low\u2010dose glucocorticoid treatment was associated with a lower risk of glaucoma in children with axial lengths \u226518\u2009mm. The same effect was not observed in children with shorter eyes. High\u2010dose glucocorticoid should be limited in children undergoing cataract surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.16746","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T10:05:08Z","timestamp":1723457108000},"page":"43-49","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparing glaucoma risk in children receiving low\u2010dose and high\u2010dose glucocorticoid treatment after cataract surgery"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9887-6331","authenticated-orcid":false,"given":"Diana Chaban\u00e9","family":"Schmidt","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Copenhagen University Hospital, Rigshospitalet  Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torben","family":"Martinussen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8933-5864","authenticated-orcid":false,"given":"Ameenat Lola","family":"Solebo","sequence":"additional","affiliation":[{"name":"Population, Policy and Practice Research and Teaching UCL Great Ormond Street Institute of Child Health  London UK"},{"name":"Great Ormond Street Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorte Ancher","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8249-5104","authenticated-orcid":false,"given":"Daniella","family":"Bach\u2010Holm","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Copenhagen University Hospital, Rigshospitalet  Glostrup Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9375-1510","authenticated-orcid":false,"given":"Line","family":"Kessel","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Copenhagen University Hospital, Rigshospitalet  Glostrup Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1091-8531(00)90009-0"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2018.04.035"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10985-018-9428-5"},{"key":"e_1_2_7_5_1","volume-title":"Steroid\u2010induced glaucoma","author":"Feroze K.B.","year":"2023"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2020.5664"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2015.1329"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-1156"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000000209"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(97)30052-9"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2005.01022.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2018.06.012"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1710-1492-9-30"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(18)30317-1"},{"key":"e_1_2_7_15_1","volume-title":"Dynamic regression models for survival data","author":"Martinussen T.","year":"2006"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(00)00357-2"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)76256-7"},{"key":"e_1_2_7_18_1","volume-title":"R: a language and environment for statistical computing","author":"R Core Team","year":"2020"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00143888"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(77)90858-3"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.15253"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-020-1115-6"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2019-314804"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2006.01.003"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/08820538.2014.959192"},{"key":"e_1_2_7_26_1","volume-title":"Childhood glaucoma: the 9th consensus report of the World Glaucoma Association 290","author":"World Glaucoma Association","year":"2013"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.16746","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T09:13:10Z","timestamp":1736241190000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.16746"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,12]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/aos.16746"],"URL":"https:\/\/doi.org\/10.1111\/aos.16746","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,12]]},"assertion":[{"value":"2024-05-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}