{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:19:36Z","timestamp":1791386376518,"version":"4.3.3"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17H04349"],"award-info":[{"award-number":["17H04349"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020953","name":"Co-creation place formation support program","doi-asserted-by":"publisher","award":["JPMJPF2201"],"award-info":[{"award-number":["JPMJPF2201"]}],"id":[{"id":"10.13039\/501100020953","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2025,2]]},"abstract":"Abstract<\/jats:title>\n \n Purpose<\/jats:title>\n To compare blood flow (BF) impairment patterns in different optic neuropathies using laser speckle flowgraphy (LSFG).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This retrospective study enrolled 24 eyes of 24 patients with non\u2010arteritic anterior ischemic optic neuropathy (NAAION), 59 eyes of 59 patients with optic neuritis (ON), 677 eyes of 677 patients with open\u2010angle glaucoma (OAG), and 110 eyes of 110 controls. The patient backgrounds of all groups were compared. Ophthalmologic findings were evaluated, adjusting for age, sex, blood pressure, pulse rate, and underlying systemic diseases with 1:1 optimal propensity score matching. We used LSFG to obtain optic nerve head (ONH) vessel\u2010area mean blur rate (MBR; ONH\u2010MV), ONH tissue\u2010area MBR (ONH\u2010MT), and choroidal MBR. The NAAION and ON groups were compared with the control and OAG groups.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Best\u2010corrected visual acuity was worse in the NAAION, ON, and OAG groups than in controls (\n p<\/jats:italic>\n \u2009<\u20090.001). Circumpapillary retinal nerve fibre layer thickness was higher in the NAAION and ON groups and lower in the OAG group than in controls (\n p<\/jats:italic>\n \u2009<\u20090.001). Compared to controls, the NAAION and OAG groups had significantly lower ONH\u2010MV, ONH\u2010MT, and choroidal MBR (\n p<\/jats:italic>\n \u2009<\u20090.05). Additionally, the NAAION group had lower ONH\u2010MV and choroidal MBR than the OAG group (\n p<\/jats:italic>\n \u2009=\u20090.003 and\n p<\/jats:italic>\n \u2009<\u20090.001, respectively) but no difference in ONH\u2010MT (\n p<\/jats:italic>\n \u2009=\u20090.857). The ON group had significantly lower ONH\u2010MV and choroidal MBR compared to the controls (\n p<\/jats:italic>\n \u2009<\u20090.001 and\n p<\/jats:italic>\n \u2009=\u20090.022, respectively) but no difference in ONH\u2010MT (\n p<\/jats:italic>\n \u2009=\u20090.773).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Optic neuropathies showed different patterns of ocular BF impairment. Therefore, LSFG can be a useful tool for differentiating optic neuropathies.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/aos.16747","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T04:39:06Z","timestamp":1723523946000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Differentiating optic neuropathies using laser speckle flowgraphy: Evaluating blood flow patterns in the optic nerve head and peripapillary choroid"],"prefix":"10.1111","volume":"103","author":[{"given":"Chiaki","family":"Yamaguchi","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Tohoku University Graduate School of Medicine Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Kiyota","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Tohoku University Graduate School of Medicine Sendai Miyagi 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