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VI was classified according to the Finnish national definitions derived from the WHO definitions. The significance of the changes in incidence and age at onset were tested with statistical tests (Kruskal\u2013Wallis, Mann\u2013Whitney <jats:italic>U<\/jats:italic> and Cochran\u2010Armitage). Two\u2010tailed <jats:italic>p<\/jats:italic>\u2010value below 0.05 was considered significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of VI due to RP has decreased from 0.96\/100\u2009000 in the 1980s to 0.55\/100 000 in the 2010s (<jats:italic>p<\/jats:italic> 0.004). The age at onset of VI has increased from 41.6 to 50.3\u2009years. The severity of VI has not changed. The incidence of HRD diagnoses has decreased from 3.66\/100\u2009000 in the 2000s to 2.86\/100\u2009000 in the 2010s (<jats:italic>p<\/jats:italic> 0.024). The age at diagnosis has risen in male patients from 42.1 to 44.5\u2009years (<jats:italic>p<\/jats:italic> 0.024).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The VI caused by RP in Finland has decreased. It develops at an older age than in the past. We hypothesize that this trend may be attributed to informed decisions by visually impaired persons to refrain from having offspring to prevent the transmission of hereditary mutations. The severity of VI due to RP has remained relatively unchanged. The incidence of HRD diagnoses has decreased, and the diagnosis occurs at an older age among men.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.16757","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T12:16:53Z","timestamp":1727439413000},"page":"85-92","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The incidence of visual impairment due to retinitis pigmentosa has declined in Finland over the last 40\u2009years"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1085-4154","authenticated-orcid":false,"given":"Paula","family":"Mosallaei","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine and Health Technology Tampere University  Tampere Finland"},{"name":"Finnish Register of Visual Impairment, Finnish Federation of the Visually Impaired  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5308-8622","authenticated-orcid":false,"given":"Petri","family":"Purola","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine and Health Technology Tampere University  Tampere Finland"},{"name":"Finnish Register of Visual Impairment, Finnish Federation of the Visually Impaired  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Tolkkinen","sequence":"additional","affiliation":[{"name":"Finnish Register of Visual Impairment, Finnish Federation of the Visually Impaired  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika","family":"Gissler","sequence":"additional","affiliation":[{"name":"Department of Knowledge Brokers Finnish Institute for Health and Welfare  Helsinki Finland"},{"name":"Academic Primary Health Care Centre  Stockholm Sweden"},{"name":"Department of Molecular Medicine and Surgery Karolinska Institute  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannu","family":"Uusitalo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine and Health Technology Tampere University  Tampere Finland"},{"name":"Finnish Register of Visual Impairment, Finnish Federation of the Visually Impaired  Helsinki Finland"},{"name":"Tays Eye Center Tampere University Hospital  Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2018.09.2605"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2010.03.004"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/09286586.2014.929710"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021\u20109681(83)90147\u20109"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12\u201011025"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2017.03.003"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109394(84)90636\u20106"},{"key":"e_1_2_6_9_1","unstructured":"Care Register for Health Care \u2010 THL. 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