{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T12:22:12Z","timestamp":1781353332653,"version":"3.54.1"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aims to characterize the clinical outcomes after allogeneic simple limbal epithelial transplantation (alloSLET) utilizing tissue from cadaveric donor eyes to address persistent corneal epithelial defects caused by limbal stem cell deficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective analysis of medical records from 20 patients, encompassing 24 eyes, who underwent alloSLET at least 2\u2009years prior. The primary endpoint was the achievement of complete epithelialization of the corneal surface by corneal epithelium. Secondary endpoints included corrected distance visual acuity (CDVA) and postoperative adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median postoperative follow\u2010up period was 36\u2009months (range, 24\u201374\u2009months). At 1, 3 and 6\u2009months post\u2010surgery, 96% of eyes demonstrated epithelialized corneal surfaces, which declined to 71% at 12\u2009months, to 54% at 24 and 36\u2009months after surgery, and to 50% thereafter. There were no significant differences in graft survival between alloSLET performed alone versus in combination with penetrating keratoplasty. However, instances of graft failure were associated with postoperative elevated intraocular pressure (IOP) and a history of multiple amniotic membrane and corneal graft transplants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>AlloSLET emerges as a viable mid\u2010term intervention for limbal stem cell deficiency\u2010associated non\u2010healing corneal epithelial defects in the absence of autologous limbal tissue. Our findings underscore the increased risk of graft failure in patients with elevated IOP and a background of multiple previous amniotic membrane and corneal graft procedures.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.16760","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T10:10:10Z","timestamp":1727431810000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Midterm results after allogeneic simple limbal epithelial transplantation from deceased\u2010donor eyes in patients with persistent corneal epithelial defects due to limbal stem cell deficiency"],"prefix":"10.1111","volume":"103","author":[{"given":"Jana C.","family":"Riedl","sequence":"first","affiliation":[{"name":"Department of Ophthalmology University Medical Center, Johannes Gutenberg University Mainz  Mainz 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