{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T04:10:36Z","timestamp":1784607036201,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271086"],"award-info":[{"award-number":["82271086"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To explore the prevalence and associated factors of a dome\u2010shaped macula (DSM) in a general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Out of the population\u2010based Beijing Eye Study cohort (<jats:italic>n<\/jats:italic>\u2009=\u20093468 participants), the investigation included all eyes with an axial length of \u226525\u2009mm, and a randomized sample of eyes with an axial length of &lt;25\u2009mm. Using optical coherence tomographic (OCT) images, we examined presence and height of DSMs, defined as an inward convexity of the foveal retinal pigment epithelium (RPE)\/Bruch's membrane (BM) line, detectable in at least two OCT scans perpendicularly orientated to each other.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study cohort consisted of 366 eyes (314 individuals) with a mean age of 63.7\u2009\u00b1\u20099.7\u2009years and a mean axial length of 24.8\u2009\u00b1\u20092.1\u2009mm (median: 25.1\u2009mm; range: 18.96\u201330.88\u2009mm). Prevalence of DSMs (found in 6\/366 eyes; 1.9%; 95%CI: 1.0, 3.0) increased from 0\/125 (0%) in non\u2010myopic eyes to 1\/152 (0.7%; 95%CI: 0.0, 2.0) in moderately myopic eyes, and to 6\/83 (7.2%; 95%CI: 1.7, 12.7) in the highly myopic group. In multivariable analysis, higher DSM prevalence corelated with longer axial length (OR: 2.05; 95%CI: 1.36, 3.08; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and higher stage of myopic macular degeneration (OR: 1.08; 95%CI: 1.01, 1.16; <jats:italic>p<\/jats:italic>\u2009=\u20090.03). The mean maximal DSM height was 139\u2009\u00b1\u2009107\u2009\u03bcm (median: 100\u2009\u03bcm; range: 25\u2013350\u2009\u03bcm). It was associated with higher stage of myopic macular degeneration (beta: 0.24; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and higher prevalence of macular BM defects (beta: 0.17; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). None of the DSMs showed a serous retinal detachment or relative choroidal thickening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Higher DSM prevalence correlated non\u2010linearly with longer axial length, with DSM height increasing with the presence of a BM defect. DSMs may be associated with an axial elongation\u2010related BM overproduction in the fundus midperiphery in all meridians.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.16764","type":"journal-article","created":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T06:11:07Z","timestamp":1727503867000},"page":"177-185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prevalence and associations of dome\u2010shaped maculas. The Beijing Eye Study"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2972-5227","authenticated-orcid":false,"given":"Jost B.","family":"Jonas","sequence":"first","affiliation":[{"name":"Rothschild Foundation Hospital Institut Fran\u00e7ais de Myopie  Paris France"},{"name":"Singapore Eye Research Institute  Singapore Singapore"},{"name":"Privatpraxis Prof Jonas und Dr. Panda\u2010Jonas  Heidelberg Germany"},{"name":"New York Eye and Ear Infirmary of Mount Sinai Icahn School of Medicine at Mount Sinai  New York New York USA"},{"name":"Beijing Visual Science and Translational Eye Research Institute (BERI), Beijing Tsinghua Changgung Hospital, Tsinghua Medicine, Tsinghua University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songhomitra","family":"Panda\u2010Jonas","sequence":"additional","affiliation":[{"name":"Privatpraxis Prof Jonas und Dr. Panda\u2010Jonas  Heidelberg Germany"},{"name":"Department of Ophthalmology, Medical Faculty Heidelberg Heidelberg University  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2386-0989","authenticated-orcid":false,"given":"Wen\u2010Bin","family":"Wei","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology and Visual Sciences Key Laboratory, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Eye Center, Beijing Tongren Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Xu","sequence":"additional","affiliation":[{"name":"Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing Institute of Ophthalmology, Beijing Tongren Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2749-7793","authenticated-orcid":false,"given":"Ya Xing","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing Institute of Ophthalmology, Beijing Tongren Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3928\/23258160-20230823-02"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.06.032"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2012.08.007"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-013-2561-7"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0178998"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-017-3587-z"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000528993"},{"key":"e_1_2_8_9_1","first-page":"186","article-title":"Dome\u2010shaped macula versus ridge\u2010shaped macula eyes in high myopia based on the 12\u2010line radial optical coherence tomography scan pattern. 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