{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T19:22:24Z","timestamp":1791832944742,"version":"4.3.4"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T00:00:00Z","timestamp":1729900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005860","name":"Helsefonden","doi-asserted-by":"publisher","award":["20\u2010B\u20100169"],"award-info":[{"award-number":["20\u2010B\u20100169"]}],"id":[{"id":"10.13039\/501100005860","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010347","name":"Fabrikant Einar Willumsens Mindelegat","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024075","name":"Region Syddanmark","doi-asserted-by":"publisher","award":["17\/15133"],"award-info":[{"award-number":["17\/15133"]}],"id":[{"id":"10.13039\/501100024075","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The purpose of this study is to investigate 3\u2010year efficacy of orthokeratology lenses (OKL) in controlling axial length progression in myopic Scandinavian children. Through a cross\u2010over design of the control group to compare the treatment efficacy in younger versus older children, with the latter having higher cycloplegic spherical refractive error (cSEQ) at treatment initiation. Further, the study aimed to evaluate the safety of the treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a continuation of the randomized controlled study Clinical study Of Near\u2010sightedness; TReatment with Orthokeratology Lenses (CONTROL study) in which the follow\u2010up period of the original intervention group, that received OKL, was extended from 18\u2009months to 36\u2009months. Meanwhile, the original control group was crossed\u2010over to OKL after the 18\u2010month follow\u2010up visit and treated for 18\u2009months. Biometry was measured using Lenstar LS900, and contact lens complications were graded according to Efron Grading Scale for Contact Lens Complications (Efron score). Mixed models were used for statistical analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nineteen subjects in the OKL group and 28 in the control group completed the CONTROL study. Hereof, 17 and 24 subjects from the OKL group and control group, respectively, agreed to participate in the CONTROL2 study. In the OKL continue group, the treatment efficacy did not decline during the 3\u2010year study period (<jats:italic>p<\/jats:italic>\u2010values for follow\u2010up visits were all \u22650.82). There was no statistically significant difference between treatment efficacy when OKL treatment was initiated in younger versus older children (<jats:italic>p<\/jats:italic>\u2010value \u22650.14 for all follow\u2010up visits). Low\u2010grade corneal staining was seen in several subjects at some point during the study, but here were no treatment\u2010requiring or sight\u2010threatening adverse events during the study period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The efficacy of myopia control by OKL was stable during 3\u2009years of treatment. Similar treatment efficacies were found regardless of the age at treatment initiation. No severe adverse events occurred during the study period.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.16775","type":"journal-article","created":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T10:08:58Z","timestamp":1729937338000},"page":"186-195","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Myopia control with orthokeratology lenses. A 3\u2010year follow\u2010up study including a cross\u2010over design: Clinical study Of Near\u2010sightedness; TReatment with Orthokeratology Lenses 2 (<scp>CONTROL2<\/scp> study)"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4496-2610","authenticated-orcid":false,"given":"T. M.","family":"Jakobsen","sequence":"first","affiliation":[{"name":"Department of Ophthalmology University Hospital of Southern Denmark, Vejle Hospital  Vejle Denmark"},{"name":"Department of Regional Health Research University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5067-5456","authenticated-orcid":false,"given":"K. B.","family":"H\u00f8eg","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospital of Southern Denmark, Vejle Hospital  Vejle Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9678-2171","authenticated-orcid":false,"given":"F.","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospital of Southern Denmark, Vejle Hospital  Vejle Denmark"},{"name":"Department of Regional Health Research University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2022.101742"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2009.161729"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1475-1313.1999.00420.x-i1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12107"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.61.4.49"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.16684"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.07.042"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-8453"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-34580-3"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14911"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0218140","article-title":"Predictive factors associated with axial length growth and myopia progression in orthokeratology","volume":"14","author":"Kim J.","year":"2019","journal-title":"PLoS One"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.61.2.22"},{"key":"e_1_2_7_14_1","article-title":"Interventions for myopia control in children: a living systematic review and network metaanalysis","volume":"2","author":"Lawrenson J.G.","year":"2023","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000001091"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/02713683.2016.1221979"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2016.4009"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.16775","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T05:41:43Z","timestamp":1739252503000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.16775"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,26]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/aos.16775"],"URL":"https:\/\/doi.org\/10.1111\/aos.16775","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,26]]},"assertion":[{"value":"2024-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}