{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:21:55Z","timestamp":1787318515680,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare vitrectomy with and without internal limiting membrane (ILM) peeling in small idiopathic macular holes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective multicentre study including consecutive eyes with \u2264250\u2009\u03bcm idiopathic macular hole treated with vitrectomy. The primary outcome was hole closure rate. Best\u2010corrected visual acuity (BCVA) change, closure patterns on optical coherence tomography, rates of external limiting membrane (ELM) and ellipsoid zone (EZ) recovery, and rate of complications were also investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 693 eyes were included. Hole closure rate was 98% in the peeling and 85% in the no\u2010peeling group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). At 12\u2009months, mean BCVA change was 0.38\u2009\u00b1\u20090.22 logMAR in the peeling and 0.45\u2009\u00b1\u20090.21 logMAR in the no\u2010peeling group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02); 66% versus 80% of eyes had a U\u2010shaped morphology, respectively; EZ recovery rate was 75% and 93%, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). In the no\u2010peeling group, eyes with a vitreomacular traction (VMT) showed a 96% closure rate, comparable to the peeling group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.40). The incidence of adverse events was similar except for dissociated optic nerve fibre layer (55% in the peeling vs. 9% in the no\u2010peeling group,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In small idiopathic macular holes, ILM peeling provides a higher closure rate compared to no\u2010peeling; however, if a VMT is present closure rates are comparable. In closed macular holes, the no\u2010peeling technique provides advantages in terms of visual outcome and anatomical recovery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.16778","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T07:53:34Z","timestamp":1728892414000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Vitrectomy in Small idiopathic\n                    <scp>MAcuLar hoLe<\/scp>\n                    (\n                    <scp>SMALL<\/scp>\n                    ) study: Internal limiting membrane peeling versus no peeling"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8881-0926","authenticated-orcid":false,"given":"Paola","family":"Marolo","sequence":"first","affiliation":[{"name":"Department of Surgical Sciences, Section of Ophthalmology University of Turin  Turin 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