{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:19:52Z","timestamp":1787501992494,"version":"build-2736575974"},"reference-count":63,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,10,20]],"date-time":"2024-10-20T00:00:00Z","timestamp":1729382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To test the prognostic role of anterior scleral substantia propria (ASSP) thickness in predicting the 3\u2010month response after half\u2010dose photodynamic therapy (PDT) in central serous chorioretinopathy (CSCR) and to assess its clinical relevance of ASSP in different CSCR phenotypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective, exploratory, multi\u2010centre cohort study conducted at IRCCS San Martino Hospital (Genoa, Italy) and Jules\u2010Gonin Eye Hospital (Lausanne, Switzerland). Demographic and clinical data, and optical coherence tomography (OCT) were collected at baseline and 3\u2009months after PDT. Based on OCT images, we categorized CSCR phenotypes and collected clinically relevant imaging metrics. ASSP thickness was obtained from four different measurements using anterior segment (AS) OCT. Multivariable regression models were performed to evaluate the distribution of ASSP thicknesses among different CSCR phenotypes and to test the prognostic role of ASSP thickness in discriminating between PDT responders (complete subretinal fluid reabsorption) and partial responders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study cohort comprised 109 Caucasian patients (82 males, 75.2%) with a total of 142 eyes: 84 eyes\n                      <jats:italic>simple<\/jats:italic>\n                      (59.1%) versus 58 eyes\n                      <jats:italic>complex<\/jats:italic>\n                      (40.9%) CSCR. A linear normal model confirmed a positive association between\n                      <jats:italic>complex<\/jats:italic>\n                      CSCR and higher ASSP thickness (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u200926.1, 95% CL\u2009=\u200912.1\/40.1,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), with a low prevalence of ciliochoroidal effusion loculations in AS\u2010OCT (1\/142 eyes, 0.7%). ASSP thickening was positively linked to the presence of posterior cystoid retinal degeneration (PCRD;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), indicating a potential role in the pathogenesis of severe CSCR phenotypes. In the subgroup of treated patients (61 eyes), 63.9% had a complete response after PDT. In these patients a logistic binary model highlighted a significantly higher risk of PDT non\u2010responsiveness (OR\u2009=\u20099.62, 95% CL\u2009=\u20092.44\/37.9,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) associated with a 60\u2010unit increase in ASSP thickness levels. By contrast, other anatomical parameters (i.e., body surface area, age, gender, axial length) showed no remarkable prognostic roles.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This research highlighted the association of ASSP thickening with\n                      <jats:italic>complex<\/jats:italic>\n                      CSCR phenotype in Caucasian patients and its role in predicting PDT efficacy. These findings enhance our comprehension of the anatomical risk factors in patients affected with CSCR and potentially guide a better understanding of non\u2010responsive cases to PDT treatment.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.16779","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T00:33:31Z","timestamp":1729470811000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Influence of scleral thickness on photodynamic therapy outcomes in central serous chorioretinopathy"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1762-3506","authenticated-orcid":false,"given":"Paolo","family":"Forte","sequence":"first","affiliation":[{"name":"Eye Unit IRCCS Ospedale Policlinico San Martino  Genoa Italy"},{"name":"DINOGMI University of Genoa  Genoa Italy"},{"name":"Department of Ophthalmology, 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