{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:30:11Z","timestamp":1790062211852,"version":"4.0.1"},"reference-count":55,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:00:00Z","timestamp":1729209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Central serous chorioretinopathy (CSC) is a prevalent exudative maculopathy. Understanding risk factors for CSC is important for disease prevention and to provide evidence\u2010based advice to patients. In this study, we systematically reviewed the literature and performed meta\u2010analysis on the association between tobacco consumption and CSC. We searched 12 literature databases on May 5, 2024, and identified 11 eligible studies of 27\u2009595 patients with CSC and 105\u2009354 control individuals. Studies were predominantly clinic\u2010based case\u2013control studies. We calculated a summary estimate of tobacco consumption as a risk factor for CSC at an odds ratio of 2.99 (95% CI: 1.82\u20134.93,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.000017), which remained statistically significant in the sensitivity analyses. The exact mechanism by which tobacco consumption contribute to the pathophysiology of CSC remains unclear, although several potential hypotheses exist. However, tobacco consumption is a modifiable behaviour and tobacco cessation is an actionable advice with which patients with CSC themselves can play a large role in disease management. Further studies are warranted to understand the impact of tobacco cessation for risk modification and for the prognosis of patients who already have CSC.\n                  <\/jats:p>","DOI":"10.1111\/aos.16782","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T09:00:16Z","timestamp":1729242016000},"page":"136-145","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Is tobacco consumption a risk factor for central serous chorioretinopathy? A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"103","author":[{"given":"Zainab","family":"Fakhril\u2010Din","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Zealand University Hospital  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Arnold\u2010Vangsted","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Rigshospitalet  Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars Christian","family":"Boberg\u2010Ans","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Innlandet Hospital Trust  Elverum Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Anguita","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Inselspital University Hospital Bern, University of Bern  Bern Switzerland"},{"name":"Moorfields Eye Hospital NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0715-6369","authenticated-orcid":false,"given":"Lorenzo Ferro","family":"Desideri","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Inselspital University Hospital Bern, University of Bern  Bern Switzerland"},{"name":"Department for Bio Medical Research University of Bern  Bern Switzerland"},{"name":"Bern Photographic Reading Center, Inselspital University Hospital Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elon H. C.","family":"van Dijk","sequence":"additional","affiliation":[{"name":"Lions Eye Institute  Perth Western Australia Australia"},{"name":"Department of Ophthalmology Sir Charles Gairdner Hospital  Perth Western Australia Australia"},{"name":"Department of Ophthalmology Leiden University Medical Centre  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5019-0736","authenticated-orcid":false,"given":"Jakob","family":"Grauslund","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Odense University Hospital  Odense Denmark"},{"name":"Department of Ophthalmology Vestfold Hospital Trust  T\u00f8nsberg Norway"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver Niels","family":"Klefter","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Rigshospitalet  Glostrup Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1822-8703","authenticated-orcid":false,"given":"\u00d6zge","family":"Yanik","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Ankara University School of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6620-5365","authenticated-orcid":false,"given":"Yousif","family":"Subhi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Zealand University Hospital  Roskilde Denmark"},{"name":"Department of Ophthalmology, Rigshospitalet  Glostrup Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.195591"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep21090"},{"key":"e_1_2_8_4_1","first-page":"1131","article-title":"In patients suffering from idiopathic central serous chorioretinopathy, anxiety scores are higher than in healthy controls, but do not vary according to sex or repeated central serous chorioretinopathy","volume":"11","author":"Bazzazi N.","year":"2015","journal-title":"Neuropsychiatric Disease and Treatment"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14655"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S115685"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2021.100994"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e318219c171"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfo.2023.05.032"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/02713683.2016.1276196"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/2749296"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-018-0158-4"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-018-3985-x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.1.86"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-76556-7"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2018-312431"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2024.101236"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/15579883211034990"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2003.09.024"},{"key":"e_1_2_8_20_1","first-page":"2023","article-title":"Cochrane handbook for systematic reviews of interventions version 6.4 (updated august 2023)","author":"Higgins J.","year":"2023","journal-title":"Cochrane"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11154437"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.4103\/2211-5056.362601"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.18502\/jovr.v18i4.14553"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2021-319403"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3341\/kjo.2017.0144"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-19-0323"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-020-04664-1"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9123891"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2017-000614"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2013-304082"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S242926"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0249073"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000529"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2005.10.012"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.3109\/08820538.2013.793728"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2016.09.003"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.19-26781"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2014.100"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40123\u2010024\u201000952\u20109"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2021.100973"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000003004"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15051033"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.19-26882"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40123-023-00658-4"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0295795"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g1151"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.5301\/ejo.5000790"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2021.100955"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.15263"},{"key":"e_1_2_8_51_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0180312","article-title":"Systemic complement activation in central serous chorioretinopathy","volume":"12","author":"Dijk E.H.C.","year":"2017","journal-title":"PLoS One"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13952"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00039"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(02)01438-1"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.18-25764"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/jebm.12141"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.16782","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T00:41:59Z","timestamp":1739234519000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.16782"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,18]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/aos.16782"],"URL":"https:\/\/doi.org\/10.1111\/aos.16782","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,18]]},"assertion":[{"value":"2024-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}